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findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.
Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures
vascular endothelial growth factor (显示 VEGF 蛋白) and Hedgehog (显示 SHH 蛋白) pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish
miR (显示 MYLIP 蛋白)-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.
Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra (显示 PDGFRA 蛋白) mutants, suggesting that PDGF (显示 PDGFA 蛋白) signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra (显示 PDGFRA 蛋白)-expressing myocardial precursors.
This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (显示 FLT1 蛋白): sflt1 (显示 FLT1 蛋白) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (显示 FLT1 蛋白) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (显示 FLT1 蛋白) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (显示 RSPO1 蛋白) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (显示 FUT1 蛋白) specification: Wnt16 (显示 WNT16 蛋白)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (显示 TGFB1 蛋白)
Tmem2 (显示 TMEM2 蛋白) regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (显示 HAND1 蛋白) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF (显示 VEGF 蛋白)), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (显示 XBP1 蛋白)/IRE1 alpha (显示 ERN1 蛋白) and ATF6 (显示 ATF6 蛋白) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (显示 FGF2 蛋白) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
H3K27me3 and VEGF expression are both significantly associated with overall survival of synovial sarcoma, and H3K27me3 is a significant independent prognostic indicator in patients with synovial sarcoma
Study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma (显示 MOK 蛋白), particularly in Asian population, while no significant association was observed in overall urologic neoplasms. [review]
Low VEGFA expression is associated with Breast Cancer.
these findings indicated that miR655 may inhibit epithelial ovarian cancer (EOC)cell proliferation and invasion by repressing VEGF. Thus, the miR655/VEGF pathway could serve as a novel therapeutic target for patients with EOC.
The VEGF protein expression in gastric cancer tissues is positively correlated with TNM (显示 ODZ1 蛋白) staging and lymph node metastasis in patients. The preoperative prediction results of MRI (显示 C7ORF49 蛋白) are well consistent with postoperative pathological results, and MRI (显示 C7ORF49 蛋白) features are correlated with lymph node metastasis in patients, which has an important guiding significance for the diagnosis and treatment of gastric cancer.
ADM (显示 ADM 蛋白) was an upstream molecule of HIF-1alpha (显示 HIF1A 蛋白)/VEGF and it promoted angiogenesis through upregulating HIF-1alpha (显示 HIF1A 蛋白)/VEGF in epithelial ovarian cancer.
The expression of VEGF was negatively correlated with miR1.
EDF1 (显示 EDF1 蛋白) is required for VEGF-induced activation of the transcriptional activity of PPARgamma (显示 PPARG 蛋白) in HUVEC cells.
Studied vascular endothelial growth factor A (VEGFA) gene +936T/C single nucleotide polymorphism; found it has no significant correlation with biliary atresia in the Southern Chinese Han population.
miR125 targeted and inhibited the expression of VEGF through target sites located in the 3' untranslated region of VEGF mRNA.
T3 thyroid hormone (显示 PTH 蛋白) stimulates the expression and secretion of VEGF by Leydig cells
Dexamethasone suppressed mRNA VEGF expression and VEGF production in cortical cells while in medullar cells only VEGF production was reduced. Introduction of IL-7 (显示 IL7 蛋白), IL-1b (显示 IL1B 蛋白) or murine thymocytes increased while addition of Semaphorin 3A (显示 SEMA3A 蛋白), SDF-1a or ACTH (显示 POMC 蛋白) decreased VEGF production by cortical epithelial cells with no influence on medullar cells.
lack of endogenous PTH (显示 PTH 蛋白) may reduce VEGF expression in bone marrow mesenchymal stem cellsderived osteoblasts.
Upregulation of podocyte VEGF decreased the number of mesangial cells via inhibition of PDGF-B (显示 PDGFB 蛋白)-mediated signaling.
These data provide a new pathological perspective on cerebellar astrogliosis in Niemann-Pick type C disease and suggest the importance of VEGF as a therapeutic target for this disease.
leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3
Mesenchymal stem cells secrete VEGF which in turn mediates the differentiation of endothelial progenitor cells into endothelial cells.
This study showed that the quantity of VEGF in the glioma microenvironment seems to be crucial for the participation of microglia/macrophages on tumor progression.
AK131850 directly competed miR (显示 MLXIP 蛋白)-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR (显示 MLXIP 蛋白)-93-5p on VEGFa.
miR203 expression may be upregulated by IL17 (显示 IL17A 蛋白) stimulation, and miR203 is a positive regulator of IL17induced VEGF secretion.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (显示 MSC 蛋白) differentiation into ECs via VEGFR-2 (显示 KDR 蛋白)-dependent induction of Sox18 (显示 SOX18 蛋白), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (显示 NOTCH1 蛋白) signaling.
interleukin-1beta-induced vascular endothelial growth factor (显示 VEGF 蛋白) in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (显示 HIF1A 蛋白).
data shows that members of the VEGF-VEGFR (显示 KDR 蛋白) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (显示 ANGPT1 蛋白) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor (显示 VEGF 蛋白) Secretion
TNF (显示 TNF 蛋白) may up-regulate VEGF and stimulate angiogenesis in the mare (显示 C16orf35 蛋白) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor (显示 VEGF 蛋白) was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3 (显示 STAT3 蛋白)-VEGF pathway in pathogenesis of psoriasis.
MiR (显示 MYLIP 蛋白)-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH (显示 COL2A1 蛋白)) via upregulating VEGF, bFGF (显示 FGF2 蛋白) and inhibiting the bone cells apoptosis through Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathway
ghrelin (显示 GHRL 蛋白) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 (显示 KDR 蛋白) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (显示 CCL2 蛋白) expression at an advanced stage of atherosclerosis in rabbits
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (显示 KLHL2 蛋白)) and expression of VEGF and MVD (显示 MVD 蛋白) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha (显示 HIF1A 蛋白)/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (显示 MMP9 蛋白) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF (显示 VEGF 蛋白)).
VEGF induces TGF-beta1 (显示 TGFB1 蛋白) expression and myofibroblast transformation after glaucoma surgery.
Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2 (显示 CCT2 蛋白))
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (显示 FBLN5 蛋白) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (显示 CXCR4 蛋白), and TGFB1 (显示 TGFB1 蛋白) expression and inhibiting choroidl endothelial cell proliferation.
Apelin (显示 APLN 蛋白) may play a role in the development of central retinal vein occlusion (CRVO). Apelin (显示 APLN 蛋白) has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 (显示 DLL4 蛋白) play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha (显示 HIF1A 蛋白) and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (显示 MMP9 蛋白) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF