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Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508
Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995
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Human ERBB3 Protein expressed in Human Cells - ABIN3216381
Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995
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identified P2RX2 (显示 P2RX2 蛋白), KCNQ5 (显示 KCNQ5 蛋白), ERBB3 and SOCS3 (显示 SOCS3 蛋白) to be associated with the progression of age-related hearing impairment
In this study, authors analyzed the immunoexpression of EGFR (显示 EGFR 蛋白), HER2 (显示 ERBB2 蛋白) (EGFR2) and HER3 (EGFR3) in 41 cases of serous borderline ovarian tumors and carcinomas, in relation to the degree of differentiation and tumor stage.
Results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 (显示 ERBB4 蛋白) subsequent to increased levels of acetyl-histone and activation of ERK (显示 EPHB2 蛋白) signaling.
miR152 was found to be involved in the proliferation and metastasis of ovarian cancer cells through repression of ERBB3 expression.
NRG1 (显示 NRG1 蛋白)-dependent activation of HER3 induces primary resistance to trastuzumab in HER2 (显示 ERBB2 蛋白)-overexpressing breast cancer cells. HER3 monoclonal antibody combined with trastuzumab may serve as a treatment choice for patients with primary resistance to trastuzumab.
This phase Ib study was designed to determine the MTD (显示 MT1E 蛋白), safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) mAb SAR256212 in combination with the oral PI3K (显示 PIK3CA 蛋白) inhibitor SAR245408 for patients with metastatic or locally advanced solid tumors.
the present study suggests that HER2 (显示 ERBB2 蛋白) has an important role in the regulation of the cancer stem-like cells phenotype in ALK translocated lung cancers that is mainly orchestrated by HER2 (显示 ERBB2 蛋白)/HER3 heterodimers.
HER3 phosphorylation by EGFR (显示 EGFR 蛋白) depends on the ability of EGFR (显示 EGFR 蛋白) to homo-oligomerize.
To determine additional resistance mechanisms to cetuximab treatment besides HER3 signaling.
Study shows ErbB3 expression was markedly decreased in suicide completers compared to controls.
Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1 (显示 NRG1 蛋白)), which acts on luminal cells via Erbb3 and Erbb4 (显示 ERBB4 蛋白) receptors.
The authors demonstrate that ErbB3 signaling is required for the embryonic development of the enteric nervous system.
These studies demonstrate that ErbB3, like ErbB4 (显示 ERBB4 蛋白), enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt (显示 AKT1 蛋白) and STAT5A (显示 STAT5A 蛋白), two targets crucial for lactation.
The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 (显示 ATOH1 蛋白) levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
Our results support a role for the hepatocellular ERBB (显示 EGFR 蛋白) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (显示 EGFR 蛋白)-ERBB3 DKO models, suggesting that EGFR (显示 EGFR 蛋白)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (显示 EGFR 蛋白) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (显示 SHH 蛋白)) stimulate branching morphogenesis (BrM (显示 SMARCA2 蛋白)) and induced synthesis of mRNAs for Ptch1 (显示 PTCH1 蛋白) protein, epidermal growth factor (EGF (显示 EGF 蛋白)) and receptors of the ErbB (显示 EGFR 蛋白) receptors ErbB1 (显示 EGFR 蛋白), ErbB2 (显示 ERBB2 蛋白) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (显示 ERBB4 蛋白) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (显示 AKT1 蛋白) pathway and promoting erbB2 (显示 ERBB2 蛋白)-driven mammary/breast tumorigenesis.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3