RFWD2 产品
(Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
Categories
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).
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Featured RFWD2 Categories
Recommended RFWD2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (6)
Cat. No.
ABIN566254
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6259497
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN7180869
Quantity
100 μg
Datasheet
Datasheet
Recommended RFWD2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380854
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended RFWD2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7555202
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7565184
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317872
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RFWD2 Products
: "Involvement of COP1 in ethylene- and light-regulated hypocotyl elongation." in: Planta, Vol. 236, Issue 6, pp. 1791-802, (2012) (PubMed).: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).
: "E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 41, pp. 17493-8, (2009) (PubMed).
: "COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35464-73, (2008) (PubMed).
Synonyms and alternative names related to RFWD2
ring finger and WD repeat domain 2 (RFWD2), ring finger and WD repeat domain 2 (Rfwd2), ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2), ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog (rfwd2.L), ring finger and WD repeat domain 2 (rfwd2), AI316802, C80879, COP1, Cop1, cop1, RFWD2, RGD1304773, RNF200, rnf200, zgc:163067Protein level used designations for RFWD2
- E3 ubiquitin-protein ligase RFWD2
- RING finger and WD repeat domain protein 2
- RING finger protein 200
- constitutive photomorphogenesis protein 1 homolog
- constitutive photomorphogenic protein (COP1)
- hCOP1
- putative ubiquitin ligase COP1
- constitutive photomorphogenic protein 1
- mCOP1
- ring finger and WD repeat domain 2
- rp11-318c24.3
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