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Human Polyclonal YBX1 Primary Antibody for IF, WB - ABIN1882002
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
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Human Polyclonal YBX1 Primary Antibody for ELISA, WB - ABIN545806
Fraser, Phillips, Zhang, van Roeyen, Muehlenberg, En-Nia, Mertens: Y-box protein-1 controls transforming growth factor-beta1 translation in proximal tubular cells. in Kidney international 2008
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Human Polyclonal YBX1 Primary Antibody for ELISA, WB - ABIN545807
Shiota, Izumi, Onitsuka, Miyamoto, Kashiwagi, Kidani, Yokomizo, Naito, Kohno: Twist promotes tumor cell growth through YB-1 expression. in Cancer research 2008
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Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366502
Stickeler, Fraser, Honig, Chen, Berget, Cooper: The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. in The EMBO journal 2001
Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366500
Dey, Robitaille, Remke, Maier, Malhotra, Gregorieff, Wrana, Taylor, Angers, Kenney: YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. in Oncogene 2016
characterization of YB-1 physical interactions with key base excision repair (BER) factors such as PARP1, PARP2, APE1, NEIL1 and pol beta and comparison of the full-length YB-1 and its C-terminally truncated nuclear form in regard to their binding affinities for BER proteins
YB1 modulated the adhesion ability of renal cell carcinoma cells by regulating ITGB8 and TGF-beta.
FOXC-2 and YB-1 may be related to the occurrence, development, invasion and metastasis of gastric carcinoma.
Data show that Y-box binding protein-1 (YBX1) promoted tumorigenesis and progression in spinal chordoma via the epidermal growth factor receptor (EGFR)/proto-oncogene proteins c-akt (AKT) pathway.
YB-1 affects multiple stages of HIV replication
The study establishes YBX1 as a posttranscriptional effector required for maintenance of epidermal homeostasis.
Phosphorylation of nuclear YB-1 after stimulation with epidermal growth factor is associated with nuclear accumulation of p90 ribosomal S6 kinase but not of YB-1.
this study identifies a novel lncRNA termed lncRNA-AWPPH which is highly expressed in hepatocellular carcinoma (HCC), indicates poor prognosis of HCC patients, and promotes HCC cell proliferation, migration, and in vivo tumor growth and metastasis via a novel regulatory mechanism of interacting with YBX1.
YB-1 regulates miR-155 expression via c-Myb in the laryngeal squamous cell carcinoma.Laryngeal squamous cell carcinoma patients with high YB-1 expression showed poor overall survival.
infiltrating CD4 + T cells promoted TGFbeta1 expression in both renal cell carcinoma and T cells and regulated renal cell carcinoma cells proliferation via modulating TGFbeta1/YBX1/ HIF2alpha signals
structural basis of the interactions between YB-1 and mRNAs carrying the aforementioned motifs
YB-1 silencing sensitized SH-SY5Y cells to cisplatin and promoted the apoptosis induced by cisplatin due to down-regulation of multidrug resistance (MDR) 1 protein via NF-kappaB signaling pathway.
These results suggest that extracellular vesicles and exosomes could play a role in the purging and intercellular transfer of excess free RNAs, including full-length transfer RNAs and other small noncoding RNAs.
YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway.
Data indicate that YB-1 translocates to the nucleus coordinately with p53 expression and is involved in gemcitabine resistance in bladder cancer suggesting that nuclear expression of YB-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer.
Results show that YBX1 expression is regulated by TP53TG1 which binds to YBX1 promoter and prevents its nuclear localization.
Kindlin-2 is up-regulated in glioma cells and acts as an oncogene. It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1/beta-catenin complex promotes EGFR transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 may be a novel strategy for glioma treatment.
Results showed that YB-1 promoted hepatocellular carcinoma (HCC) cell proliferation, migration and colony formation. Also, YB-1 was found to increased drug resistance in HCC. These findings suggested that YB-1 was a key factor in HCC tumorigenesis and maintained the HCC initiating cell population.
Furthermore, use of both indirubin 3'-oxime and actinomycin D in combination increased the anticancer effect on HepG2 cells. Indirubin 3'-oxime is a novel and efficient inhibitor of anticancer agent-induced YB-1 nuclear translocation.
It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated.
The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines.
results prove direct inhibitory action of YB-1 on its mRNA translation, while the positive effect of PABP is realized through displacing YB-1 from the regulatory element
his is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury.
YB-1 orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.
Monocytic YB-1 has prominent and distinct roles for cellular feed-forward crosstalk and resolution of inflammatory processes by its ability to regulate cell differentiation and cytokine/chemokine synthesis.
YB-1 is induced by Shh in CGNPs
this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2
In conclusion, TGF-beta signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis.
Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs, suggesting their roles in further regulation of the pluripotent state of ESCs.
In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 and Sp1, and was then gradually replaced under the control of both MyoD and myogenin.
YB-1 is a novel intracellular target of activated protein C in renal ischemia-reperfusion injury
miR-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein.
YB-1 was revealed in a population of Cajal bodies in 2-cell mouse embryos but not in other cells studied.
The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis.
The formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-1, which promotes MMTV virus assembly.
our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses.
Results indicate that both CD4(+) and CD8(+) T cells were involved in the anti-neuroblastoma responses induced by YB-1 immunization combined with Treg depletion.
findings show heterotopic cardiac transplant resulted in accumulation of 50-kDa YB-1 polypeptide within the polyribosome-enriched cytosol proximal to cardiac intercalated discs; YB-1 may govern cell response in the transplanted heart through its ability to bind and protect injury-activated mRNA transcripts that are prioritized for translation to assure graft adaptation
Extracellular inhibitory targeting of YB-1 potently induces glomerular Notch-3 receptor expression.
These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation.
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression
B box-binding protein
, CCAAT-binding transcription factor I subunit A
, DNA-binding protein B
, Y-box transcription factor
, Y-box-binding protein 1
, enhancer factor I subunit A
, major histocompatibility complex, class II, Y box-binding protein I
, nuclease sensitive element binding protein 1
, nuclease-sensitive element-binding protein 1
, CCAAT-binding transcription factor 1 subunit A
, DNA binding protein B
, Y box transcription factor
, enhancer factor 1 alpha
, enhancer factor 1 subunit A
, FRG Y
, frg y1
, frog Y-box proteins
, Y-box binding protein 1