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Human Polyclonal YBX1 Primary Antibody for IF, WB - ABIN1882002
Osada, Uno, Mineta, Kameoka, Takahashi, Terao: Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta. in Molecular ecology 2010
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Human Polyclonal YBX1 Primary Antibody for ELISA, WB - ABIN545806
Fraser, Phillips, Zhang, van Roeyen, Muehlenberg, En-Nia, Mertens: Y-box protein-1 controls transforming growth factor-beta1 translation in proximal tubular cells. in Kidney international 2008
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Human Polyclonal YBX1 Primary Antibody for ELISA, WB - ABIN545807
Shiota, Izumi, Onitsuka, Miyamoto, Kashiwagi, Kidani, Yokomizo, Naito, Kohno: Twist promotes tumor cell growth through YB-1 expression. in Cancer research 2008
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Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366502
Stickeler, Fraser, Honig, Chen, Berget, Cooper: The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. in The EMBO journal 2001
Human Polyclonal YBX1 Primary Antibody for ICC, IF - ABIN4366500
Dey, Robitaille, Remke, Maier, Malhotra, Gregorieff, Wrana, Taylor, Angers, Kenney: YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. in Oncogene 2016
MiR-137 can exhibit a tumor-suppressive function in MPM by targeting YBX1. YBX1 knockdown significantly reduces tumor growth, migration, and invasion of MPM cells.
High YB1 expression is associated with liver metastasis of colorectal cancer.
Results demonstrated that YB-1 translocated into the nuclei of gastric cancer cells exposed to doxorubicin hydrochloride, suggesting its important role in chemoresistance. Through modulating the expression of different ABC transporters , YB-1 and STAT3 act synergistically in chemoresistance and cell invasion of gastric cancer cells.
YBX1 participates in HOXC-AS3-mediated gene transcriptional regulation in the tumorigenesis of gastric cancer.
characterization of YB-1 physical interactions with key base excision repair (BER) factors such as PARP1, PARP2, APE1, NEIL1 and pol beta and comparison of the full-length YB-1 and its C-terminally truncated nuclear form in regard to their binding affinities for BER proteins
YB1 modulated the adhesion ability of renal cell carcinoma cells by regulating ITGB8 and TGF-beta.
FOXC-2 and YB-1 may be related to the occurrence, development, invasion and metastasis of gastric carcinoma.
Data show that Y-box binding protein-1 (YBX1) promoted tumorigenesis and progression in spinal chordoma via the epidermal growth factor receptor (EGFR)/proto-oncogene proteins c-akt (AKT) pathway.
YB-1 affects multiple stages of HIV replication
The study establishes YBX1 as a posttranscriptional effector required for maintenance of epidermal homeostasis.
Phosphorylation of nuclear YB-1 after stimulation with epidermal growth factor is associated with nuclear accumulation of p90 ribosomal S6 kinase but not of YB-1.
this study identifies a novel lncRNA termed lncRNA-AWPPH which is highly expressed in hepatocellular carcinoma (HCC), indicates poor prognosis of HCC patients, and promotes HCC cell proliferation, migration, and in vivo tumor growth and metastasis via a novel regulatory mechanism of interacting with YBX1.
YB-1 regulates miR-155 expression via c-Myb in the laryngeal squamous cell carcinoma.Laryngeal squamous cell carcinoma patients with high YB-1 expression showed poor overall survival.
infiltrating CD4 + T cells promoted TGFbeta1 expression in both renal cell carcinoma and T cells and regulated renal cell carcinoma cells proliferation via modulating TGFbeta1/YBX1/ HIF2alpha signals
structural basis of the interactions between YB-1 and mRNAs carrying the aforementioned motifs
YB-1 silencing sensitized SH-SY5Y cells to cisplatin and promoted the apoptosis induced by cisplatin due to down-regulation of multidrug resistance (MDR) 1 protein via NF-kappaB signaling pathway.
These results suggest that extracellular vesicles and exosomes could play a role in the purging and intercellular transfer of excess free RNAs, including full-length transfer RNAs and other small noncoding RNAs.
YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway.
Data indicate that YB-1 translocates to the nucleus coordinately with p53 expression and is involved in gemcitabine resistance in bladder cancer suggesting that nuclear expression of YB-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer.
Results show that YBX1 expression is regulated by TP53TG1 which binds to YBX1 promoter and prevents its nuclear localization.
The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines.
results prove direct inhibitory action of YB-1 on its mRNA translation, while the positive effect of PABP is realized through displacing YB-1 from the regulatory element
his is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury.
YB-1 orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.
Monocytic YB-1 has prominent and distinct roles for cellular feed-forward crosstalk and resolution of inflammatory processes by its ability to regulate cell differentiation and cytokine/chemokine synthesis.
YB-1 is induced by Shh in CGNPs
this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2
In conclusion, TGF-beta signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis.
Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs, suggesting their roles in further regulation of the pluripotent state of ESCs.
In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 and Sp1, and was then gradually replaced under the control of both MyoD and myogenin.
YB-1 is a novel intracellular target of activated protein C in renal ischemia-reperfusion injury
miR-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein.
YB-1 was revealed in a population of Cajal bodies in 2-cell mouse embryos but not in other cells studied.
The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis.
The formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-1, which promotes MMTV virus assembly.
our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses.
Results indicate that both CD4(+) and CD8(+) T cells were involved in the anti-neuroblastoma responses induced by YB-1 immunization combined with Treg depletion.
findings show heterotopic cardiac transplant resulted in accumulation of 50-kDa YB-1 polypeptide within the polyribosome-enriched cytosol proximal to cardiac intercalated discs; YB-1 may govern cell response in the transplanted heart through its ability to bind and protect injury-activated mRNA transcripts that are prioritized for translation to assure graft adaptation
Extracellular inhibitory targeting of YB-1 potently induces glomerular Notch-3 receptor expression.
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression
B box-binding protein
, CCAAT-binding transcription factor I subunit A
, DNA-binding protein B
, Y-box transcription factor
, Y-box-binding protein 1
, enhancer factor I subunit A
, major histocompatibility complex, class II, Y box-binding protein I
, nuclease sensitive element binding protein 1
, nuclease-sensitive element-binding protein 1
, CCAAT-binding transcription factor 1 subunit A
, DNA binding protein B
, Y box transcription factor
, enhancer factor 1 alpha
, enhancer factor 1 subunit A
, FRG Y
, frg y1
, frog Y-box proteins
, Y-box binding protein 1