抗Rat (Rattus) SETD3 抗体:
抗Human SETD3 抗体:
抗Mouse (Murine) SETD3 抗体:
Study reports structural and molecular determinant(s) of target specificity of actin histidine vs. lysine in the active site of SETD3. To facilitate the methyl transfer reaction, SETD3 provides a local environment that promotes deprotonation of the target nitrogen N3 of histidine (and concomitant protonation of N1).
CircSETD3 inhibits the growth of HCC partly through the circSETD3/miR-421/MAPK14 pathway.
SETD3 protein is the actin-specific histidine N-methyltransferase.
data reveal a new SETD3-dependent methylation-based signaling pathway at chromatin that regulates VEGF expression under normoxic and hypoxic conditions.
these data elucidated that a GSK3beta-FBXW7beta-dependent mechanism controls SETD3 protein levels during the cell cycle and attenuates its oncogenic role in liver tumorigenesis.
Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.
MAF1, RNF7 and SETD3 are identified as PCNA-associated proteins in human cells and given this interaction with PCNA, Maf1, RNF7, and SetD3 are potentially involved in DNA replication, DNA repair, or associated processes.
results identify a mammalian histidine methyltransferase and uncover a pivotal role for SETD3 and actin His73 methylation in the regulation of smooth muscle contractility; data also support the broader hypothesis that protein histidine methylation acts as a common regulatory mechanism
SETD3 is a H3K4/K36 methyltransferase and plays an important role in the transcriptional regulation of muscle cell differentiation
Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).
SET domain-containing protein 3
, histone-lysine N-methyltransferase setd3
, endothelial differentiation inhibitory protein D10