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IXL is a subunit of the mammalian Mediator complex.
Overexpression of IXL in COS-7 cells inhibits the transcriptional activities of SRE and AP-1 (显示 FOSB 抗体), suggesting that the IXL protein may act as a transcriptional suppressor in mitogen-activated protein kinase (显示 MAPK1 抗体) signaling pathway to mediate cellular functions.
IXL is required for cancer cell survival in 19q13-amplified tumors.
MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003
, mediator of RNA polymerase II transcription subunit 29