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Human Polyclonal ADA Primary Antibody for ICC, IF - ABIN4278373
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
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Cow (Bovine) Polyclonal ADA Primary Antibody for WB - ABIN2784608
Ferrante, Martire, Pepponi, Varani, Vincenzi, Ferraro, Beggiato, Tebano, Popoli: Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease. in Neurobiology of disease 2014
this study shows that ADA is biomarker candidate for endometriosis
this study characterizes the long-term outcome of ADA-deficient patients, who survived 5 or more years after therapy
ADA levels were found to be higher among patients, and revealed a possible link between evening rise and severity of auditory hallucinations as well as morning rise and severity of avolition-apathy in patients with schizophrenia.
In this study, we compared the activity of human adenosine deaminase (hADA) expressed in transgenic seeds of three different plant species: pea (Pisum sativum L.), Nicotiana benthamiana L. and tarwi (Lupinus mutabilis Sweet). All three species were transformed with the same expression vector containing the hADA gene driven by the seed-specific promoter LegA2 with an apoplast targeting pinII signal peptide.
Simvastatin reversed IL-13 (显示 IL13 抗体)-suppressed adenosine deaminase activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin (显示 SPP1 抗体) expression through the direct inhibition of IL-13 (显示 IL13 抗体)-activated STAT6 (显示 STAT6 抗体) pathway in COPD (显示 ARCN1 抗体).
Mitochondrial Damage and Apoptosis Induced by Adenosine Deaminase Inhibition and Deoxyadenosine in Human Neuroblastoma (显示 ARHGEF16 抗体) Cell Lines
Adenosine deaminases ADA1 (显示 TADA1 抗体) and ADA2 (显示 TADA2A 抗体) (ADAs (显示 AGPS 抗体)) decrease the level of adenosine by converting it to inosine, which serves as a negative feedback mechanism. These results suggest the existence of a new mechanism, where the activation and survival of immune cells is regulated through the activities of ADA2 (显示 TADA2A 抗体) or ADA1 (显示 TADA1 抗体) anchored to the cell surface.
Patients with tuberculous pleurisy who had high ADA values had a higher probability of manifesting pulmonary tuberculosis. High ADA values may help predict contagious pleuroparenchymal tuberculosis. The most common pulmonary involvement of tuberculous pleurisy showed a centrilobular nodular pattern.
our analysis shows that, mononuclear cells secretes ADA in response to leishmanial infection and the elevated serum ADA activity is associated with VL and PKDL (显示 PKD2L1 抗体), and serum ADA activity can be used as prognostic marker to monitor the course of the treatment.
association between the occurrence of polycystic ovary syndrome with altered ADA activity and genetic distribution of G22A and A4223C polymorphisms of the ADA1 (显示 TADA1 抗体) gene
Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice
Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice
Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39 (显示 ENTPD1 抗体)/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine.
ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation.
The catalytic mechanism of Mus (显示 TRPV6 抗体) musculus adenosine deaminase (ADA) has been studied by quantum mechanics and two-layered ONIOM calculations
Adenosine deaminase is necessary but not sufficient to confer puromycin aminonucleoside sensitivity to podocytes.
adenosine deaminase deficient results in deoxy-ATP accumulation and leads to reduced thymic T cell production
Transactivation by a duodenum-specific enhancer requires functional GATA4 (显示 GATA4 抗体) binding sites
ADA-deficient B cells exhibit a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, and suggest a role for ADA in the survival of cells during antigen-dependent responses.
This study provides a basis for investigating the folding kinetics of murine ADA and folding mechanisms of (beta/alpha)8-barrel proteins using 19F NMR sepctroscopy.
study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase (显示 NT5E 抗体), and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
It was concluded that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS (显示 ROS1 抗体) production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic adenosine deaminase (ADA) activity may contribute to the inflammatory process.
Crystal structure of CD26/dipeptidyl-peptidase IV (显示 DPP4 抗体) in complex with adenosine deaminase
the transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations
This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state.
Data demonstrate that dipeptidyl peptidase II (显示 DPP7 抗体) can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV (显示 DPP4 抗体).
after the immunotherapy, the rabbits showed an increase in the E-ADA activity when compared with control (78.62%), contributing for the change in the immune response.
both oxygenation of the tissue and adenosine deaminase activity in the medium support both growth and proliferation of wing discs.
Our results indicate that ADA inhibition, besides increasing the interstitial adenosine level, intensifies the atrial A1 adenosinergic function in another (thyroid hormone (显示 PTH 抗体)-sensitive) way, suggesting a new mechanism of action of ADA inhibition
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
, adenosine deaminase