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Extracellular Hsp70 (显示 HSP70 ELISA试剂盒) and Hsp90 (显示 HSP90 ELISA试剂盒), either in soluble form or secreted as part of exosomes from tumor cells, are responsible for tumor induction of cachexia.
a surface population of Hsp90 (显示 HSP90 ELISA试剂盒) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (显示 TGFB1 ELISA试剂盒)-activated fibroblasts.
Hsp90 (显示 HSP90 ELISA试剂盒) is highly expressed on the cell surface of melanoma cells, and synthetic agents that target Hsp90 (显示 HSP90 ELISA试剂盒) are promising cancer therapeutic drugs
These findings identify the Ezh2 (显示 EZH2 ELISA试剂盒)-Hsp90 (显示 HSP90 ELISA试剂盒) interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease.
Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (显示 HSP90 ELISA试剂盒) and the PI3K/AKT (显示 AKT1 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) pathway in prostate cancer.
genes respond to HSP90 (显示 HSP90 ELISA试剂盒) inhibition in a manner dependent on their genomic location with regard to strain-specific endogenous retroviruses-insertion sites.
PABPN1 (显示 PABPN1 ELISA试剂盒) interacts with and is stabilized by heat shock protein 90 (显示 HSP90 ELISA试剂盒).
Hyperacetylation of Hsp90 (显示 HSP90 ELISA试剂盒) is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 (显示 HDAC6 ELISA试剂盒) inhibitors increase Hsp90 (显示 HSP90 ELISA试剂盒) acetylation and modulate GR chaperone dynamics.
These findings demonstrate a critical role of Hsp90 (显示 HSP90 ELISA试剂盒) in lipopolysaccharide (LPS (显示 TLR4 ELISA试剂盒)) signaling, and a potential involvement of the heat shock response in LPS (显示 TLR4 ELISA试剂盒)-induced preconditioning.
Phosphoproteomics, protein expression inference and signaling pathway prediction analysis of P2RX7 (显示 P2RX7 ELISA试剂盒) signaling mediators pointed to HSPA2 (显示 HSPA2 ELISA试剂盒) and HSP90 (显示 HSP90 ELISA试剂盒) proteins.
Data demonstrate that Hsp90alpha and Hsp90beta exhibit similar interactions with co-chaperones, but significantly different behaviors with respect to substrate interactions under stress conditions.
We found that the nutrient value of the culturing medium and the length of induction had significant effect on Hsp90 (显示 HSP90 ELISA试剂盒) production in Escherichia coli. Our fast, single-day purification protocol resulted in a stable, well-folded and pure sample that was resistant to degradation in a reproducible manner.
Data show that C allele of rs2282151 was associated with increased expression level of heat shock protein 90 alpha (显示 HSP90AA1 ELISA试剂盒) family class B member 1 (HSP90AB1).
Hsp90beta induced endothelial cell-dependent tumor angiogenesis by activating VEGFRs transcription.
The authors find that the interaction between sB-Raf (显示 RAF1 ELISA试剂盒) and the Hsp90 chaperone (显示 HSP90 ELISA试剂盒) system is based on contacts with the M domain of Hsp90 (显示 HSP90 ELISA试剂盒), which contributes in forming the ternary complex with Cdc37 (显示 CDC37 ELISA试剂盒) as long as the kinase is not stabilized by nucleotide.
High HSP90B expression is associated with laryngeal carcinoma.
The expression level of Hsp90AB1 in lung cancer tissues was significantly higher than that in normal lung tissue and was associated with lung cancer pathological type and overall survival in lung adenocarcinoma patients.
We revealed that Hsp90A (显示 HSP90AA1 ELISA试剂盒) and Hsp90B are partly colocalized with heparan sulfate proteoglycans (HSPGs) on the cell surface and that this colocalization was sensitive to heparin.
Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.
HSP90AB1: Helping the good and the bad
These results suggest a means by which the hsp90beta interaction could prevent apo (显示 C9orf3 ELISA试剂盒)-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain.
Data from Xenopus laevis embryo suggest hsp90alpha and hsp90Beta genes are conserved among vertebrates, and are differentially regulated in a tissue, stress, and development stage-specific manner.
Studied the nucleotide polymorphism within the HSP90AB1 gene (SNP g.4338T>C) in Indian breeds of dairy cattle.
Association analysis revealed that the T allele at SNP g.4338T>C of the HSP90AB1 gene improved heat tolerance in cattle. Allele T was 100% in White Lamphun animals, 84% in Mountain cattle, and 18% in Holstein Friesian heifers.
This study showed that ubiquitinated ALK5 (显示 TGFBR1 ELISA试剂盒) and phosphorylated heat shock protein 27 (显示 HSP27 ELISA试剂盒) specifically accumulate in the cytoskeleton fraction, and ALK1 (显示 ACVRL1 ELISA试剂盒) and ALK5 (显示 TGFBR1 ELISA试剂盒) interact with heat shock protein 90(HSP90 (显示 HSP90 ELISA试剂盒)).
the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Mapped six genes (EIF4G3, HSP90, RBBP6 (显示 RBBP6 ELISA试剂盒), IL8 (显示 IL8 ELISA试剂盒), TERT (显示 TERT ELISA试剂盒), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
Hsp90 is involved in opposing signaling pathways of cartilage homeostasis and catabolic responses are more sensitive to Hsp90 inhibition than are anabolic responses.
This gene encodes a member of the heat shock protein 90 family\; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
Heat Shock Protein 90, endoplasmic reticulum
, heat shock protein 90B
, heat shock protein hsp90 beta
, hsp90 beta
, HSP 84
, heat shock 84 kDa
, heat shock 90kDa protein 1, beta
, heat shock protein 90kDa alpha (cytosolic), class B member 1
, heat shock protein HSP 90-beta
, heat shock protein 1, beta
, heat shock protein, 84 kDa 1
, retinal degeneration slow protein
, tumor-specific transplantation 84 kDa antigen
, heat shock protein 90-beta
, heat shock protein 90kDa alpha, class B member 1
, heat shock cognate protein HSP 90-beta
, heat shock protein 90 beta
, heat shock 90kD protein 1, beta
, heat shock 90kDa protein beta
, Heat shock protein HSP 90-beta-like protein
, heat shock protein 90