Use your antibodies-online credentials, if available.
抗Mouse (Murine) CXCR4 抗体:
抗Rat (Rattus) CXCR4 抗体:
抗Human CXCR4 抗体:
Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900744
Griffiths, Dolezal, Cao, Nilsson, See, Pfleger, Roche, Gorry, Pow, Viduka, Lim, Lu, Chang, Murray-Rust, Kvansakul, Perugini, Dogovski, Doerflinger, Zhang, Parisi, Casey, Nuttall, Foley: i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. in The Journal of biological chemistry 2016
Show all 28 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900745
Hansson, Olesen, Peterslund, Engberg, Kahn, Winzi, Klein, Maddox-Hyttel, Serup: A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. in Developmental biology 2009
Show all 21 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN4898488
Peled, Abraham, Avivi, Rowe, Beider, Wald, Tiomkin, Ribakovsky, Riback, Ramati, Aviel, Galun, Shaw, Eizenberg, Hardan, Shimoni, Nagler: The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 17 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for ICC, IF - ABIN261500
Hasegawa, McLeod, Prow, Merges, Grebe, Lutty: Vascular precursors in developing human retina. in Investigative ophthalmology & visual science 2008
Show all 16 Pubmed References
Human Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4900746
Albanesi, Scarponi, Pallotta, Daniele, Bosisio, Madonna, Fortugno, Gonzalvo-Feo, Franssen, Parmentier, De Pità, Girolomoni, Sozzani: Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. in The Journal of experimental medicine 2009
Show all 15 Pubmed References
Mouse (Murine) Monoclonal CXCR4 Primary Antibody for CyTOF, FACS - ABIN4899088
Rider, Carmi, Guttman, Braiman, Cohen, Voronov, White, Dinarello, Apte: IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 15 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for ICC, IF - ABIN4301203
Kulbe, Hagemann, Szlosarek, Balkwill, Wilson: The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells. in Cancer research 2005
Show all 14 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for FACS, IF (p) - ABIN730888
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 12 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for IHC (p), WB - ABIN3044349
Liu, Wang, Wang, Wang: Anticancer effects of chemokine receptor 4(CXCR4) gene silenced by CXCR4-siRNA in nude mice model of ovarian cancer. in Cell biochemistry and biophysics 2014
Show all 12 Pubmed References
Human Polyclonal CXCR4 Primary Antibody for WB - ABIN3042911
Lin, Zheng, Shen, Tang, Chen, Sun, Zhao, Yao: Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. in Medical oncology (Northwood, London, England) 2011
Show all 11 Pubmed References
bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
tested for possible epistasis between Tbx1 and the CXCL12 signalling axis by examining Tbx1 and Cxcl12 double heterozygotes as well as Tbx1/Cxcl12/Cxcr4 triple heterozygotes, but failed to identify any exacerbation of the Tbx1 haploinsufficient arch artery phenotype
CXCL14 is expressed by islet delta-cells where it may have paracrine effects to inhibit insulin secretion in a CXCR4/CXCR7-independent manner through reductions in beta-cell ATP levels.
SDF-1/CXCR4 pathway may play an important role in fracture healing following bone mesenchymal stem cell transplantation.
LincRNA-p21 promotes MSC migration and survival capacity through HIF-1a/CXCR4 and CXCR7 pathway under hypoxic preconditioning in vitro.
These data define dynamic changes in CXCR4 expression as a marker for intrathymic selection events, and show its role in T-cell development is restricted to pre-CD4(+)CD8(+) stages.
these findings identify the CXCR4-CXCL12 axis as a potential therapeutic target likely due to its importance for antibody-secreting cell homing and survival
Results suggest that during the development and migration of granule cell progenitors (GCPs), CXCR4 on the plasma membrane is phosphorylated, internalized, sorted to the centrosomes, Golgi apparatus, and lysosomes, and functionally regulates GCP differentiation, migration and positioning.
The down-regulation of CXCR4 by inducing small interfering RNA inhibits the proliferation of Th17 cells and to promote the expression of IL-6, IL-17, and IL-23.
superparamagnetic iron oxide nanoparticles also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in mesenchymal stem cells.
Results indicate that exosomes secreted from highly metastatic hepatocarcinoma-F cells promote Hca-P with (low metastatic potential) cell migration and invasion possibly through horizontal transfer of CXCR4. The exosomal CXCR4 released from Hca-F cells stimulate LECs proliferation and lymphangiogenesis, this probably is due to SDF-1alpha/CXCR4 axis mediated MMP-9, MMP-2 and VEGF-C secretions.
findings suggest that periodontal CXCR4 signaling in several cell types in Porphyromonas gingivalis-induced periodontal inflammation depresses alveolar bone resorption in periodontitis. CXCR4 signaling might be a target for therapeutic intervention to prevent alveolar bone resorption in periodontitis
CXCL12-CXCR4 signalling is essential for the correct patterning of aortic arches and pulmonary arteries during development.
Study demonstrates that CXCR4/CXCL12 axis can limit oxidative stress injury in hematopoietic stem cells (HSCs) by reducing mitochondrial oxidative stress. Disruption of CXCR4 receptor in mice leads to increased endogenous production of reactive oxygen species, resulting in p38 MAPK activation, increased DNA double-strand breaks and apoptosis leading to marked reduction in HSC repopulating potential.
the Sdf-1 receptors - Cxcr4 and Cxcr7, as well as signaling pathways induced by these molecules in primary myoblasts, as well as various stem cells, were studied.
Results provide evidence showing that CXCR4 plays an important role in regulating biological functions associated with B16 liver metastasis.
Using an RNA-mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced Rap1 activation. We have shown that SDF-1alpha-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor.
Cardiac stem cells express CXCR4. Activation of c-kit signalling by SCF promotes migration of CSCs with increased phosphorylation of CXCR4-serine 339, p38 mitogen-activated protein kinase (p38 MAPK) and extracellular regulated protein kinases 1/2 (ERK1/2).
nitration on Tyr7 under inflammatory conditions is a novel natural posttranslational regulatory mechanism of CXCL12 which may downregulate the CXCR4-mediated inflammatory and tumor-promoting activities of CXCL12
Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1alpha in a manner critically dependent on signaling via the SDF-1alpha-CXCR4 axis.
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway
CXCR4 interacted with PI4KIIIalpha membrane targeting machinery recruiting them to the plasma membrane for PI4P production.CXCR4 regulates PI4KIIIalpha activity and mediates prostate tumor metastasis.
Our findings revealed the critical role of CXCR4 in promoting progression of inflammatory colorectal cancer through recruiting immunocytes and enhancing cytoskeletal remodeling by lncRNA XIST/ miR-133a-3p/ RhoA signaling. These results provide novel potential therapeutic targets for hindering CXCL12/CXCR4-induced CRC progression.
CXCR4 is a G-protein-coupled chemokine receptor, which is expressed on white blood cells and hematopoetic stem cells.
MiR-622 inhibits CRC angiogenesis by suppressing the CXCR4-VEGFA signaling axis.
In vitro human parvovirus B19-infected circulating angiogenic cells showed up-regulation of surface CXCR4 with increased migratory capacity further enhanced by elevated SDF-1alpha concentrations. Overexpression of the human parvovirus B19 capsid protein VP2 was associated with this effect.
These results suggest that CXCR3-B is an indicator of poor prognosis and may also be a chemotherapeutic target.
Our results suggest that enhanced CXCR4 expression on CD4+ T-cells was positively correlated with increased plasma IL-17A concentrations in patients with AA. In addition, the level of CXCR4 expression on T-cells and IL-17A concentration were both positively correlated with AA severity.
this study indicated that CXCL12, CXCR4, and CXCR7 were differentially expressed and regulated in u-THP-1 and d-THP-1 cells in response to external stimuli. Importantly, we reported here a novel observation that uncoupling exists between transcriptional and translational regulation of CXCR4, 7 expressions by differentiation and TLR stimuli.
Study found higher levels of CXCR4 both at the gene and protein level in synovial sarcoma (SS) tumors and presents evidence for its role of CXCR4 as a potential target of miR494.
GRO-alpha from OSF-associated fibroblasts paracrinally promotes oral malignant transformation and significantly contributes to OSCC development.
a novel role for GRK2 as a target of TCR signaling that is responsible for TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that signals via PI3Kgamma/PREX1 to mediate cytokine production.
Working Toward a Genomic Prognostic Classification of Waldenstrom Macroglobulinemia: C-X-C Chemokine Receptor Type 4 Mutation and Beyond.
his study uncovered a novel mechanism of colorectal tumorigenesis through the CXCR7/CXCR4 heterodimer-induced histone demethylation. Inhibition of CXCR7/CXCR4 heterodimer-induced histone demethylation could be an effective strategy for the prevention and treatment of colorectal cancer.
A feed-forward loop between nuclear translocation of CXCR4 and HIF-1alpha promotes renal cell carcinoma metastasis.
Results indicate that CXCR4 expression confers a proinvasive phenotype to ovarian carcinoma cells.
This article reviews the significance of MYD88(L265P) and CXCR4(WHIM) mutations in the diagnosis and treatment of Waldenstrom Macroglobulinemia [review]
Knockdown of amplified in breast cancer 1 (AIB1) greatly reduced C-X-C motif chemokine receptor 4 (CXCR4) gene expression at both the transcription and protein levels.
These data revealed that CXCR4-mediated Akt activation and signaling require endocytosis and the Rab5-effector EEA1 but not APPL1, suggesting a role for EEA1-positive endosomes in Akt signaling.
The present study demonstrated that UCA1 inhibition exerted an antigrowth and antimigration role in MHCC97 cells through regulating miR-301a and CXCR4 expression
ALDH1A3 is the key isoform that contributed to Aldefluor positivity in cell lines. Knocking down ALDH1A3 in different cancer cells conferred opposite phenotypes due to differential effects on CXCR4 expression. There was a significant negative correlation between ALDH1A3 and CXCR4 in 58 human cell lines.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 and CXCL2 and of chemokine receptors CCR2, CCR5, and CXCR4 following coronary angioplasty
Necessary for the migrations of massive numbers of cells during gastrulation.
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 expression resulted in increased SDF-1-induced RF/6A cell migration and tube formation.
The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.
Hoxb8a is induced by and cooperates with Wnt signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
Required specifically in germ cells for their chemotaxis; mutant germ cells are able to activate the migratory programme, but fail to undergo directed migration towards their target tissue, resulting in randomly dispersed germ cells
SDF-1/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
sdf1-expressing mesodermal cells, which overlie the endodermal layer, guide the cxcr4a-expressing endodermal cells to the dorsal side of the embryo during gastrulation
Wnt/beta-catenin signaling in leader cells informs coordinated migration via differential regulation of the two chemokine receptors, cxcr4b and cxcr7b.
Data show that CXCR7, but not CXCR4, is required for proper tangential migration of facial motoneurons.
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4