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Human Polyclonal PHLDA2 Primary Antibody for IF (p), IHC (p) - ABIN872459
Jin, Qiao, Luan, Shang et al.: The expression of the imprinted gene pleckstrin homology-like domain family A member 2 in placental tissues of preeclampsia and its effects on the proliferation, migration and invasion of trophoblast ... in Clinical and experimental pharmacology & physiology 2015
Show all 2 Pubmed References
Human Monoclonal PHLDA2 Primary Antibody for ELISA, WB - ABIN563272
Suzuki, Shaw, Kaneko-Ishino, Ishino, Renfree: Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting. in BMC evolutionary biology 2011
Human Polyclonal PHLDA2 Primary Antibody for IHC (p), IHC - ABIN250091
Qian, Frank, OKeefe, Dao, Zhao, Yuan, Wang, Keating, Walsh, Tycko: The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. in Human molecular genetics 1997
Human Polyclonal PHLDA2 Primary Antibody for IHC, WB - ABIN2787605
Dai, Huang, Li, Meng, Wang, Guo: TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. in Carcinogenesis 2011
Authors demonstrated that TSSC3 was an independent prognostic marker for overall survival in osteosarcoma, and positive ATG5 expression associated with positive TSSC3 expression suggested a favorable prognosis for patients. Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma.
RanBP9/TSSC3 complex cooperatively suppress metastasis via downregulation of Src-dependent Akt pathway to expedite mitochondrial-associated anoikis.
PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion.
TSSC3 was a prognostic marker in osteosarcoma.
TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta
Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.
PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts.
The gene expression pattern of CDKN1C, H19, IGF2, KCNQ1 and PHLDA2 genes was evaluated using RT-PCR.
elevated expression in placenta of growth restricted pregnancies [review]
results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction
TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth
TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells
A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight.
The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction.
TSSC3 has a potent tumor suppressor role in osteosarcoma, probably by inhibition of growth and induction of apoptosis via the mitochondrial apoptosis pathway.
PHLDA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Expression levels of PHLDA2 gene were upregulated in the first trimester pregnancy
PHLDA2 gene is imprinted, with preferential expression from the maternal allele in placenta and liver.
Transcripts of TSSC3 could not be detected in human oocytes and preimplantation embryos.
Exposure of trophoblasts to hypoxia in vitro markedly reduced the expression of PHLDA2.
Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.
data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve
TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway.
Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.
A critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta is identified.
deletion causes placental overgrowth
Embryonic expression of Ipl in mice
Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs.
In the present study, a 259 base pair-specific sequence for IPL gene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified in IPL exon 1. Variable imprinting status of this gene was observed in different developmental stages.
Quantitative allelic sequencing supports maternal expression of PHLDA2 in fetal liver and placental tissues using an interbreed swine model.
genes critical for placental development were altered in nuclear transfer placentas, including an imprinted gene. Allele-specific changes in the permissive histone mark in the PHLDA2 promoter indicate misregulation of imprinting in clones.
imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues, were assessed in cattle.
proper expression levels of the imprinted genes CDKN1C and PHLDA2 are critical for embryo development
Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.
This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
pleckstrin homology-like domain, family A, member 2
, pleckstrin homology-like domain family A member 2
, Imprinted in placenta and liver protein
, beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein
, imprinted in placenta and liver protein
, p17-Beckwith-Wiedemann region 1 C
, p17-Beckwith-Wiedemann region 1C
, tumor suppressing subchromosomal transferable fragment cDNA 3
, tumor suppressing subtransferable candidate 3
, tumor-suppressing STF cDNA 3 protein
, tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
, tumor-supressing STF cDNA 3
, protein 50C15
, tumor-suppressing subchromosomal transferable fragment 3