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Serum ANGPTL6 levels increased in patients with a hypothyroid status, and both TSH and free T4 levels are associated with ANGPLT6 levels, suggesting a possible association between thyroid function and ANGPTL6 levels.
AGF concentrations is significantly higher in patients with type 2 diabetes as compared to controls.
In the second trimester, Angptl6 levels are higher in women with subsequent pregnancy-induced hypertension.
There are no significant differences in maternal Angptl6/ARP5 serum level between pre-eclamptic women and normally pregnant control women
Serum AGF levels are significantly higher in subjects with polycystic ovary syndrome than those in the healthy control group.
Interaction between alpha6 integrin and E-cadherin (显示 CDH1 ELISA试剂盒) drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6.
ANGPTL6 affects resting metabolic rate (RMR), significantly improves lipid profile and slightly improves insulin (显示 INS ELISA试剂盒) levels and insulin (显示 INS ELISA试剂盒) sensitivity, as well.
serum AGF levels were paradoxically increased in metabolic syndrome, in comparison with data from animal experiments and data on sex, age, and waist circumference
findings suggest that AGF affects epidermal proliferation and thereby plays a role in the wound healing process
showed that AGF is a secreted protein, AGF directly promotes chemotactic activity of vascular endothelial cells, and AGF directly induces a permeability change in the local vasculature.
mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 (显示 FGF21 ELISA试剂盒) production in adipose tissue and cultured adipocytes.
In addition to pronounced angiogenesis and epidermal hyperplasia, marked enlargement of dermal lymphatic vessels was observed in UV-B-exposed Angptl6/AGF transgenic mice.
we show that (>80%) of the AGF-deficient mice die at about embryonic day 13, while the surviving AGF-deficient mice develop marked obesity, lipid accumulation in skeletal muscle and liver, and insulin (显示 INS ELISA试剂盒) resistance accompanied by reduced energy expenditure
Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
Activation of an ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-eNOS (显示 NOS3 ELISA试剂盒)-NO pathway is a crucial signaling mechanism by which angiopoietin-related growth factor increases blood flow through induction of angiogenesis and arteriogenesis.
The present results provided evidence that polymorphisms of ANGPTL6 gene were associated with growth and slaughter traits.
developmental expression of Angptl1 (显示 ANGPTL1 ELISA试剂盒), 2 and 6 in zebrafish
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
angiopoietin-like protein 6
, angiopoietin-related growth factor
, angiopoietin-related protein 5
, angiopoietin-related protein 6
, Angiopoietin-related growth factor
, angiopoietin-like protein 6 alpha form
, angiopoietin-like protein 6 beta form
, angiopoietin-like 6
, angiopoietin-related protein 6-like
, actin-like protein 3
, actin-related protein 3
, actin-related protein 3 homolog (yest)
, ARP3 actin-related protein 3 homolog