PTPN22 抗体
(Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
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Latest Publications for our PTPN22 抗体
: "High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis." in: PLoS ONE, Vol. 7, Issue 8, pp. e42783, (2012) (PubMed).
Aliases for PTPN22 抗体
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) 抗体protein tyrosine phosphatase, non-receptor type 22 (PTPN22) 抗体
protein tyrosine phosphatase, non-receptor type 22 (Ptpn22) 抗体
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