(Protein tyrosine Phosphatase, Non-Receptor Type 14 (PTPN14))
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010].
Barr, Debreczeni, Eswaran, Knapp: "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution." in: Proteins, Vol. 63, Issue 4, pp. 1132-6, (2006) (PubMed).
Wadham, Gamble, Vadas, Khew-Goodall: "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin." in: Molecular biology of the cell, Vol. 14, Issue 6, pp. 2520-9, (2003) (PubMed).
Aliases for PTPN14 抗体
protein tyrosine phosphatase, non-receptor type 14 (PTPN14) 抗体 protein tyrosine phosphatase, non-receptor type 14 (Ptpn14) 抗体 C130080N23Rik 抗体 OTTMUSG00000022087 抗体 PEZ 抗体 PTP36 抗体