IL1A 蛋白
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北京 101111
Quick Overview for IL1A 蛋白 (ABIN988012)
抗原
See all IL1A 蛋白生物活性
宿主
资源
纯度
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序列
- SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQ
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产品特性
- Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of mouse D10S cells is less than 0.001 ng/ml, corresponding to aof 1 x 109 IU/mg
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内毒素水平
- Level Less than 1EU/µg of rHuIL-1alpha as determined by LAL method
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
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储存条件
- 4 °C
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- IL1A (Interleukin 1 alpha (IL1A))
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别名
- Interleukin-1 alpha (IL-1alpha)
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背景
- IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine. Synonym: Interleukin-1 alpha ( IL-1alpha) , Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
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分子量
- Approximately 18.0 kDa, a single non-glycosylated polypeptide chain containing 159 amino acids.
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途径
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
抗原
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