Interferon Tau 蛋白
宿主: 绵羊
宿主: Yeast (Pichia pastoris)
Recombinant
> 95 % by SDS-PAGE and HPLC analyses.
Active
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- 抗原 See all Interferon Tau products
- Interferon Tau (Interferon tau-2)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 绵羊
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资源
- Yeast (Pichia pastoris)
- 序列
- CYLSRKLMLD ARENLKLLDR MNRLSPHSCL QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN S
- 产品特性
- Fully biologically active when compared to IFN-alpha. The specific activity determined by a viral resistance assay is no less than 1.0 × 107 IU/mg.
- 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- Level Less than 1EU/µg of rOvIFN-tau as determined by LAL method
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
- 储存条件
- 4 °C
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- 抗原
- Interferon Tau (Interferon tau-2)
- 别名
- Interferon-tau (IFN-Tau) (Interferon Tau 产品)
- 别名
- IFN-tau-c2 Protein, IFNT Protein, IFNT1 Protein, TP-1 Protein, interferon tau Protein, IFNT2 Protein
- 背景
- IFN-tau is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-ª/beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOvIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN- tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN- tau was shown to downregulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE. Synonym: Interferon-tau ( IFN-tau ), Ovine. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
- 分子量
- Approximately 19.9 kDa, a single non-glycosylated polypeptide chain containing 172 amino acids.
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