Purified recombinant Human TACI protein Expression System: E.coli Bioactivity: Determined by its ability to bl °Ck human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/mL.
TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors, NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRILstimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Alternative Names: TNFRSF13B protein, Transmembrane activator and CAML interactor protein