TGFB1 蛋白
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北京 101111
Quick Overview for TGFB1 蛋白 (ABIN935827)
抗原
See all TGFB1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
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产品特性
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Purified recombinant Human TGF beta 1 protein
Expression System: CHO cells
Bioactivity: The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in 10 mM Citric Acid pH 3.0 .
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缓冲液
- Lyophilized from 10 mM Sodium Citrate, pH 3.5.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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别名
- TGF beta 1
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背景
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The three mammalian isoforms of TGF beta, TGF beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.
Alternative Names: TGF beta-1 protein, Differentiation inhibiting factor protein, TGFB1 protein, TGF beta 1 protein, TGF beta -1 protein, Transforming Growth Factor-beta1 protein, TGF beta 1, Cartilage-inducing factor protein, TGF beta -1, TGF-1b protein, TGF beta 1 -
途径
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
抗原
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