RIPK1 Protein (AA 1-294)
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Quick Overview for RIPK1 Protein (AA 1-294) (ABIN7939505)
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See all RIPK1 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 1-294
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原理
- Recombinant RIPK1 (1-294) protein
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Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 1-671) protein (GST tag)
RIPK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 562-671) protein (GST tag)RIPK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 292-438) protein (His tag)RIPK1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant RIPK1 (1-294) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
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别名
- RIPK1
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背景
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Protein Background: RIPK1 is a serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1. Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis. In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner and thereby activates the MAP3K5-JNK apoptotic cascade.
Short Description: Recombinant RIPK1 (1-294) protein that includes amino acids 1-294 of human RIPK1 protein (accession number NP_003795.2) was expressed in a baculovirus expression system, and contains an N-terminal His and FLAG tag. The molecular weight of the protein is 37.93 kDa.
Aliases: RIP-1, RIP1, AIEFL, Cell Death Protein RIP
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途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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