c-MET Protein (AA 956-1390)
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Quick Overview for c-MET Protein (AA 956-1390) (ABIN7939268)
抗原
See all c-MET (MET) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 956-1390
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原理
- Recombinant MET (956-1390) protein
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Met Proto-Oncogene (MET) (AA 25-932) protein (His-Avi Tag)
MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
Met Proto-Oncogene (MET) (AA 25-930) (Active) protein (His tag)MET 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Met Proto-Oncogene (MET) (AA 25-932) (Active) protein (Biotin,His-Avi Tag)MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Met Proto-Oncogene (MET) (AA 26-125) protein (GST tag)MET 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Met Proto-Oncogene (MET) (Active) protein (His tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Met Proto-Oncogene (MET) (AA 956-1390) (Active) protein (GST tag,His tag)MET 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Met Proto-Oncogene (MET) (Active) protein (Fc Tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
Met Proto-Oncogene (MET) (AA 956-1080) protein (His-IF2DI Tag)MET 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Met Proto-Oncogene (MET) (AA 25-932) protein (His tag)MET 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Met Proto-Oncogene (MET) (AA 25-932) protein (Fc Tag)MET 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant MET (956-1390) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- c-MET (MET) (Met Proto-Oncogene (MET))
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别名
- MET
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背景
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Protein Background: MET (Hepatocyte growth factor receptor), also known as AUTS9, c-Met, DA11, DFNB97, HGFR and RCCP2. MET is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinaseAKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts.
Short Description: Recombinant MET (956-1390) protein that includes amino acids 956-1390 of human MET protein (accession number NP_000236.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 50.30 kDa.
Aliases: Hepatocyte growth factor receptor, AUTS9, c-Met, DA11, DFNB97, HGFR, RCCP2
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途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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