MERS-Coronavirus Spike Protein (RBD) (His tag)
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- 抗原 See all MERS-Coronavirus Spike (MERS-CoV S) products
- MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))
- 蛋白类型
- Recombinant
- 产品特性
- RBD
- 宿主
- Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
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资源
- HEK-293 Cells
- 标记
- This MERS-Coronavirus Spike protein is labelled with His tag.
- 原理
- Recombinant MERS-CoV Spike RBD Protein
- 序列
- EAKPSGSVVE QAEGVECDFS PLLSGTPPQV YNFKRLVFTN CNYNLTKLLS LFSVNDFTCS QISPAAIASN CYSSLILDYF SYPLSMKSDL SVSSAGPISQ FNYKQSFSNP TCLILATVPH NLTTITKPLK YSYINKCSRL LSDDRTEVPQ LVNANQYSPC VSIVPSTVWE DGDYYRKQLS PLEGGGWLVA SGSTVAMTEQ LQMGFGITVQ YGTDTNSVCP KLEFANDTKI ASQLGNCVEY
- 特异性
- Glu367-Tyr606
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
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MERS-Coronavirus Spike Protein (MERS-CoV S) (Active) protein (His tag)
MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
MERS-Coronavirus Spike Protein (MERS-CoV S) (Active) protein (His tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
MERS-Coronavirus Spike Protein (MERS-CoV S) (Active) protein (His tag,ECD)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE Active
MERS-Coronavirus Spike Protein (MERS-CoV S) (RBD) (Active) protein (His tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
MERS-Coronavirus Spike Protein (MERS-CoV S) protein (His tag,Biotin)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE.
MERS-Coronavirus Spike Protein (MERS-CoV S) protein (His tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
MERS-Coronavirus Spike Protein (MERS-CoV S) protein (His tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE.
MERS-Coronavirus Spike Protein (MERS-CoV S) protein (rFc Tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by SDS-PAGE
MERS-Coronavirus Spike Protein (MERS-CoV S) (AA 18-751) (Active) protein (His tag)MERS-CoV S 宿主: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- 抗原
- MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))
- 别名
- MERS-CoV Spike (MERS-CoV S 产品)
- 物质类
- Viral Protein
- 背景
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Description: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, dipeptidyl peptidase-4, APN, aminopeptidase N, CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1, Sia, sialic acid, O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion, Defines the range of the hosts and specificity of the virus, Main component to bind with the neutralizing antibody, Key target for vaccine design, Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Name: MERS-CoV Spike RBD
- 基因ID
- 14254594
- UniProt
- K0BRG7
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