Decorin Protein (DCN) (His tag)
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- 抗原 See all Decorin (DCN) 蛋白
- Decorin (DCN)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Decorin protein is labelled with His tag.
- 原理
- Active Recombinant Human Decorin/PG-S2/DCN Protein
- 序列
- GPFQQRGLFD FMLEDEASGI GPEVPDDRDF EPSLGPVCPF RCQCHLRVVQ CSDLGLDKVP KDLPPDTTLL DLQNNKITEI KDGDFKNLKN LHALILVNNK ISKVSPGAFT PLVKLERLYL SKNQLKELPE KMPKTLQELR AHENEITKVR KVTFNGLNQM IVIELGTNPL KSSGIENGAF QGMKKLSYIR IADTNITSIP QGLPPSLTEL HLDGNKISRV DAASLKGLNN LAKLGLSFNS ISAVDNGSLA NTPHLRELHL DNNKLTRVPG GLAEHKYIQV VYLHNNNISV VGSSDFCPPG HNTKKASYSG VSLFSNPVQY WEIQPSTFRC VYVRSAIQLG NYK
- 特异性
- Gly17-Lys359
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human DCN at 1 μg/mL (100 μL/well) can bind DCN Rabbit pAb with a linear range of 0.5-141 ng/mL.
- Top Product
- Discover our top product DCN 蛋白
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Decorin (DCN) (AA 1-359) protein (GST tag)
DCN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Decorin (DCN) protein (His tag)DCN 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Decorin (DCN) (AA 36-195) protein (His-IF2DI Tag)DCN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Decorin (DCN) (AA 35-354) protein (His tag)DCN 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Decorin (DCN) (AA 31-354) protein (His tag)Crystallography grade DCN 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- 抗原
- Decorin (DCN)
- 别名
- Decorin/PG-S2/DCN (DCN 产品)
- 别名
- CSCD Protein, DSPG2 Protein, PG40 Protein, PGII Protein, PGS2 Protein, SLRR1B Protein, DC Protein, mDcn Protein, cscd Protein, dspg2 Protein, pg40 Protein, pgii Protein, pgs2 Protein, slrr1b Protein, decorin Protein, decorin L homeolog Protein, DCN Protein, Dcn Protein, dcn.L Protein, dcn Protein
- 背景
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Description: Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Name: DCN,CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B,decorin,Decorin
- 基因ID
- 1634
- UniProt
- P07585-1
- 途径
- Glycosaminoglycan Metabolic Process
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