Cathepsin S Protein (CTSS) (His tag)
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- 抗原 See all Cathepsin S (CTSS) 蛋白
- Cathepsin S (CTSS)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Cathepsin S protein is labelled with His tag.
- 原理
- Active Recombinant Human Cathepsin S Protein
- 序列
- QLHKDPTLDH HWHLWKKTYG KQYKEKNEEA VRRLIWEKNL KFVMLHNLEH SMGMHSYDLG MNHLGDMTSE EVMSLMSSLR VPSQWQRNIT YKSNPNRILP DSVDWREKGC VTEVKYQGSC GACWAFSAVG ALEAQLKLKT GKLVSLSAQN LVDCSTEKYG NKGCNGGFMT TAFQYIIDNK GIDSDASYPY KAMDQKCQYD SKYRAATCSK YTELPYGRED VLKEAVANKG PVSVGVDARH PSFFLYRSGV YYEPSCTQNV NHGVLVVGYG DLNGKEYWLV KNSWGHNFGE EGYIRMARNK GNHCGIASFP SYPEI
- 特异性
- Gln17-Ile331
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >1390 pmol/min/μg.
- Top Product
- Discover our top product CTSS 蛋白
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Cathepsin S (CTSS) (AA 1-331) protein (GST tag)
CTSS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin S (CTSS) protein (His tag)CTSS 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Cathepsin S (CTSS) (Active) protein (His tag)CTSS 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Cathepsin S (CTSS) (AA 115-331) protein (His tag)Crystallography grade CTSS 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin S (CTSS) (AA 123-340) protein (His tag)Crystallography grade CTSS 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of 50 mM MES,100 mM NaCl, pH 6.5.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- Cathepsin S (CTSS)
- 别名
- Cathepsin S (CTSS 产品)
- 别名
- ctss-a Protein, MGC69026 Protein, ctss-b Protein, MGC80097 Protein, ctss.1 Protein, CTSS Protein, ctss Protein, cats Protein, cathepsin S Protein, cathepsin S L homeolog Protein, cathepsin S S homeolog Protein, Cathepsin S Protein, CTSS Protein, Ctss Protein, ctss.L Protein, ctss.S Protein, ctss Protein, cats Protein
- 背景
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Description: Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 Molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, it has been implicated in the pathogenesis of several diseases such as Alzheimer's disease and degenerative disorders associated with the cells of the mononuclear phagocytic system.
Name: CTSS
- 基因ID
- 1520
- UniProt
- P25774
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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