alpha 2 Antiplasmin Protein (His tag)
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- 抗原 See all alpha 2 Antiplasmin (SERPINF2) 蛋白
- alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This alpha 2 Antiplasmin protein is labelled with His tag.
- 原理
- Active Recombinant Human Serpin F2/Alpha-2-antiplasmin Protein
- 序列
- MEPLGRQLTS GPNQEQVSPL TLLKLGNQEP GGQTALKSPP GVCSRDPTPE QTHRLARAMM AFTADLFSLV AQTSTCPNLI LSPLSVALAL SHLALGAQNH TLQRLQQVLH AGSGPCLPHL LSRLCQDLGP GAFRLAARMY LQKGFPIKED FLEQSEQLFG AKPVSLTGKQ EDDLANINQW VKEATEGKIQ EFLSGLPEDT VLLLLNAIHF QGFWRNKFDP SLTQRDSFHL DEQFTVPVEM MQARTYPLRW FLLEQPEIQV AHFPFKNNMS FVVLVPTHFE WNVSQVLANL SWDTLHPPLV WERPTKVRLP KLYLKHQMDL VATLSQLGLQ ELFQAPDLRG ISEQSLVVSG VQHQSTLELS EVGVEAAAAT SIAMSRMSLS SFSVNRPFLF FIFEDTTGLP LFVGSVRNPN PSAPRELKEQ QDSPGNKDFL QSLKGFPRGD KLFGPDLKLV PPMEEDYPQF GSPK
- 特异性
- Met28-Lys491
- 纯度
- > 90 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 0.1 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <0.23 nM.
- Top Product
- Discover our top product SERPINF2 蛋白
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Alpha2 Antiplasmin (SERPINF2) (AA 28-491) protein (His tag)
SERPINF2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Alpha2 Antiplasmin (SERPINF2) (AA 27-490) protein (His tag)SERPINF2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Alpha2 Antiplasmin (SERPINF2) (AA 28-491) protein (His tag)SERPINF2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Alpha2 Antiplasmin (SERPINF2) (AA 380-491) protein (His-IF2DI Tag)SERPINF2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Alpha2 Antiplasmin (SERPINF2) (AA 1-491) protein (GST tag)SERPINF2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Alpha2 Antiplasmin (SERPINF2) protein (Fc Tag)SERPINF2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Alpha2 Antiplasmin (SERPINF2) (Active) protein (His tag)SERPINF2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- 抗原
- alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))
- 别名
- Serpin F2/Alpha-2-antiplasmin (SERPINF2 产品)
- 别名
- A2AP Protein, AAP Protein, ALPHA-2-PI Protein, API Protein, PLI Protein, serpin Protein, AI747498 Protein, Pli Protein, Serpimf2 Protein, serpinf2 Protein, serpinf2l Protein, wu:fd57d08 Protein, Dmrs91 Protein, Pedf Protein, serpin family F member 2 Protein, serpin family F member 1 Protein, serine (or cysteine) peptidase inhibitor, clade F, member 2 Protein, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a Protein, SERPINF2 Protein, Serpinf2 Protein, SERPINF1 Protein, serpinf2a Protein, Serpinf1 Protein
- 背景
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Description: SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, Serpin F2 is also an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta also express this protein at a moderate level.SerpinF2 is one of the inhibitors of fibrinolysis. It is a specific plasmin inhibitor, which degrades fibrin and various other proteins. Consequently, the protein plays the dominant role in regulating the blood clotting pathway. Mutations in SerpinF2 gene lead to alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases.
Name: SERPINF2,A2AP,AAP,ALPHA-2-PI,API,PLI
- 基因ID
- 5345
- UniProt
- P08697
- 途径
- Regulation of Systemic Arterial Blood Pressure by Hormones
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