Cyclin D1 Protein (CCND1) (AA 1-295) (His tag)
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- 抗原 See all Cyclin D1 (CCND1) 蛋白
- Cyclin D1 (CCND1)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-295
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Cyclin D1 protein is labelled with His tag.
- 序列
- Met 1-Ile 295
- 产品特性
- A DNA sequence encoding the Human cyclin D1/Ccnd1 protein (P25322) (Met 1-Ile 295) was expressed with N-His.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCND1 蛋白
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Cyclin D1 (CCND1) (AA 1-295) protein (GST tag)
CCND1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin D1 (CCND1) (AA 11-285) protein (His-IF2DI Tag)CCND1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Cyclin D1 (CCND1)
- 别名
- cyclin D1 (CCND1 产品)
- 别名
- BCL1 Protein, D11S287E Protein, PRAD1 Protein, U21B31 Protein, AI327039 Protein, CycD1 Protein, Cyl-1 Protein, bcl-1 Protein, cD1 Protein, cb161 Protein, cycd1 Protein, etID37810.7 Protein, fb52e01 Protein, fc45c08 Protein, fc83a12 Protein, id:ibd1198 Protein, wu:fb52e01 Protein, wu:fc45c08 Protein, wu:fc83a12 Protein, ccnd1b Protein, prad1 Protein, ccnd1 Protein, ccnd1a Protein, bcl1 Protein, d11s287e Protein, u21b31 Protein, CCND1 Protein, cyclin D1 Protein, cyclin D1 S homeolog Protein, cyclin D1 L homeolog Protein, CCND1 Protein, Ccnd1 Protein, ccnd1 Protein, ccnd1.S Protein, ccnd1.L Protein
- 背景
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Background: Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase. The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation.
Synonym: B cell leukemia 1,BCL 1,ccnd1,Cd1,Cyl 1,G1/S specific cyclin D1,PRAD1
- 分子量
- 32.34 kDa
- UniProt
- P25322
- 途径
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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