Quick Overview for FZD7 蛋白 (ABIN7491647)
抗原
蛋白类型
宿主
资源
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原理
- Human FZD7 full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Frizzled Family Receptor 7 (FZD7) protein (Fc Tag)
FZD7 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Frizzled Family Receptor 7 (FZD7) (AA 1-574) protein (GST tag)FZD7 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Frizzled Family Receptor 7 (FZD7) (AA 33-185) protein (Fc Tag)FZD7 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE.
Frizzled Family Receptor 7 (FZD7) (AA 33-185) protein (His tag)FZD7 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- FZD7 (Frizzled Family Receptor 7 (FZD7))
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别名
- FZD7
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背景
- Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
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分子量
- The human full length FZD7 protein has a MW of 63.6 kDa
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UniProt
- O75084
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途径
- WNT signaling, Stem Cell Maintenance
抗原
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