NPC1L1 Protein (His tag)
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- 抗原 See all NPC1L1 蛋白
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This NPC1L1 protein is labelled with His tag.
- 原理
- Recombinant human NPC1L1 protein with C-terminal 6xHis tag
- 特异性
- NPC1L1 (Glu22-Ser284) 6xHis tag
- 产品特性
- Extracellular Domain Protein
- 纯度
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- Discover our top product NPC1L1 蛋白
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NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 1258-1359) protein (His tag)
Crystallography grade NPC1L1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 22-284) protein (His tag)Crystallography grade NPC1L1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 373-632) protein (His tag)Crystallography grade NPC1L1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 904-1139) protein (His tag)Crystallography grade NPC1L1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 21-284) protein (His tag)Crystallography grade NPC1L1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 374-632) protein (His tag)Crystallography grade NPC1L1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 868-1113) protein (His tag)Crystallography grade NPC1L1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 22-1359) protein (rho-1D4 tag)Crystallography grade NPC1L1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1) (AA 21-1333) protein (rho-1D4 tag)Crystallography grade NPC1L1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- 别名
- NPC1L1 (NPC1L1 产品)
- 别名
- NPC1L1 Protein, 9130221N23Rik Protein, Gm243 Protein, NPC11L1 Protein, NPC1 like intracellular cholesterol transporter 1 Protein, NPC1 like 1 Protein, NPC1-like 1 Protein, NPC1L1 Protein, npc1l1 Protein, Npc1l1 Protein
- 背景
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NPC1-like intracellular cholesterol transporter 1, Niemann-Pick C1-like protein 1
Description: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] - 分子量
- predicted molecular mass of 28.8 kDa after removal of the signal peptide. The apparent molecular mass of NPC1L1-His is 35-55 kDa due to glycosylation.
- UniProt
- Q9UHC9
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