SCUBE2 Protein (AA 441-659) (Fc Tag)
SCUBE2
宿主: 人
宿主: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 抗原 See all SCUBE2 products
- SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 441-659
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SCUBE2 protein is labelled with Fc Tag.
- 原理
- Recombinant human SCUBE2 (441-659) protein with C-terminal human Fc tag
- 特异性
- SCUBE2 (Asp441-Asn659 ) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- SCUBE2 (Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2))
- 别名
- SCUBE2 (SCUBE2 产品)
- 别名
- CEGB1 Protein, CEGF1 Protein, CEGP1 Protein, 4932442O19Rik Protein, Cegf1 Protein, Cegp1 Protein, RGD1563998 Protein, Scube2-ps1 Protein, wu:fc27f08 Protein, you Protein, signal peptide, CUB domain and EGF like domain containing 2 Protein, signal peptide, CUB domain, EGF-like 2 Protein, SCUBE2 Protein, Scube2 Protein, scube2 Protein
- 背景
- CEGP1, Scube/YouLipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function]
- 分子量
- predicted molecular mass of 50.2 kDa after removal of the signal peptide. The apparent molecular mass of SCUBE2(441-659)-hFc is 35-55 kDa due to glycosylation.
- UniProt
- Q9NQ36
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