IL-9 Protein (Fc Tag)
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- 抗原 See all IL-9 (IL9) 蛋白
- IL-9 (IL9) (Interleukin 9 (IL9))
- 蛋白类型
- Recombinant
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宿主
- Cynomolgus
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资源
- HEK-293 Cells
- 标记
- This IL-9 protein is labelled with Fc Tag.
- 原理
- Recombinant Cynomolgus IL9 protein with C-terminal human Fc tag
- 特异性
- IL9 (Arg19-Ile144) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- Discover our top product IL9 蛋白
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Interleukin 9 (IL9) (AA 19-144) protein (Fc Tag)
IL9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (His tag)IL9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (Fc Tag)IL9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (His tag)IL9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (His tag)IL9 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 9 (IL9) (AA 1-144) protein (GST tag)IL9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- IL-9 (IL9) (Interleukin 9 (IL9))
- 别名
- IL9 (IL9 产品)
- 别名
- IL9 Protein, IL-9 Protein, Il-9 Protein, P40 Protein, HP40 Protein, interleukin 9 Protein, IL9 Protein, il9 Protein, Il9 Protein
- 背景
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Interleukin-9, IL-9, Cytokine P40, T-cell growth factor P40
Description: Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects the differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells synergizes with TGF-β1 to differentiate naive CD4 T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3 CD4 Treg cells in vitro, and the absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight the role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses. - 分子量
- predicted molecular mass of 40.0 kDa after removal of the signal peptide.
- UniProt
- P15248
- 途径
- JAK/STAT Signaling
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