ITGAV/ITGB8 Protein (Biotin,His-Avi Tag)
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- 抗原 See all ITGAV/ITGB8 products
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This ITGAV/ITGB8 protein is labelled with Biotin,His-Avi Tag.
- 原理
- Biotinylated Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free
- 序列
- Phe 31 - Val 988 & Gly 22 - Leu 681
- 产品特性
- Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 22 - Leu 681 (Accession # P43406-1 & Q0VBD0-1).
- 纯度
- 95,00 %
- 内毒素水平
- 1.0 EU per μg
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Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-993) protein (His tag)
ITGAV/ITGB8 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB8 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-988) (Active) protein (His tag)ITGAV/ITGB8 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Integrin alpha V beta 8 (ITGAV/ITGB8) (AA 31-992) protein (His tag,AVI tag,Biotin)ITGAV/ITGB8 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- 说明
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Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB8 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 150 mM NaCl, pH 7.5
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))
- 别名
- Integrin alpha V beta 8 (ITGAV/ITGB8 产品)
- 背景
- Synonyms:Integrin alpha V beta 8,ITGAV&ITGB8,Description:Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
- 分子量
- 114.2 kDa | 77.5 kDa
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