ANG2 Protein (Fc Tag)
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- 抗原 See all ANG2 products
- ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))
- 蛋白类型
- Recombinant
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宿主
- 猕猴
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资源
- 人细胞
- 标记
- This ANG2 protein is labelled with Fc Tag.
- 原理
- Recombinant Rhesus Macaque Angiopoietin-2/ANG2 (C-Fc)
- 序列
- Tyr19-Phe495
- 产品特性
- Recombinant Rhesus Macaque Angiopoietin-2 is produced by our Mammalian expression system and the target gene encoding Tyr19-Phe495 is expressed with a Fc tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- 说明
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90-120 kDa
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ANG2 (Angiogenin, Ribonuclease A Family, Member 2 (ANG2))
- 别名
- ANG2 (ANG2 产品)
- 别名
- Angrp Protein, Rnase5b Protein, angiogenin, ribonuclease A family, member 2 Protein, angiogenin 2 Protein, Ang2 Protein, ANG2 Protein
- 背景
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Background: Angiopoietin-2 (Ang-2, also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of either Ang-1 or full-length Ang-2 to Tie-2. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.
Synonym: AGPT2, ANG2, ANG-2, angiopoietin 2, Angiopoietin-2, angiopoietin-2a, angiopoietin-2B, angiopoitin 2, ANGPT2, Tie2-ligand
- 分子量
- 81.7 kDa
- NCBI登录号
- XM_001097949
- 途径
- Carbohydrate Homeostasis
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