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UBE2L6 Protein (His tag)

UBE2L6 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 96 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317347
发货至: 中国
  • 抗原 See all UBE2L6 蛋白
    UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))
    蛋白类型
    Recombinant
    宿主
    • 7
    • 1
    • 1
    资源
    • 3
    • 2
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This UBE2L6 protein is labelled with His tag.
    原理
    Recombinant Human Ube2L6 Protein (His Tag)
    序列
    Met 1-Ser 153
    产品特性
    A DNA sequence encoding the human UBE2L6 isoform 1 (O14933-1) (Met 1-Ser 153) was expressed, with a polyhistide tag at the N-terminus.
    纯度
    > 96 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product UBE2L6 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 20 mM Tris, 0.1 % Brij35, pH 8.5
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6 (UBE2L6))
    别名
    Ube2L6 (UBE2L6 产品)
    别名
    UBE2L6 Protein, RIG-B Protein, UBCH8 Protein, 2810489I21Rik Protein, Ubce8 Protein, Ubcm8 Protein, UbcM8 Protein, ubiquitin conjugating enzyme E2 L6 Protein, ubiquitin-conjugating enzyme E2L 6 Protein, UBE2L6 Protein, Ube2l6 Protein
    背景

    Background: UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modification. By doing so, E2s differentiate effects on downstream substrates, either with a single Ub/UBL molecule or as a chain. UBCH8 is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. UBCH8 functions in the E6/E6-AP-induced ubiquitination of p53/TP53 and promotes ubiquitination and subsequent proteasomal degradation of FLT3. At protein level, it is present in natural killer cells.

    Synonym: Ubiquitin/ISG15-Conjugating Enzyme E2 L6, Retinoic Acid-Induced Gene B Protein, RIG-B, UbcH8, Ubiquitin Carrier Protein L6, Ubiquitin-Protein Ligase L6, UBE2L6, UBCH8

    分子量
    19.6 kDa
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