UCHL1 Protein (His tag)
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- 抗原 See all UCHL1 蛋白
- UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 大鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This UCHL1 protein is labelled with His tag.
- 原理
- Recombinant Rat UCHL1/PGP9.5 Protein (His Tag)(Active)
- 序列
- Glu 2-Ala 223
- 产品特性
- A DNA sequence encoding the rat UCHL1 (Q00981) (Glu 2-Ala 223) was fused with a polyhistidine tag at the N-terminus.
- 纯度
- > 97 % as determined by SDS-PAGE
- Biological Activity Comment
- Measured by the hydrolysis of UbiquitinAMC. The specific activity is >100 pmoles/min/μg.
- Top Product
- Discover our top product UCHL1 蛋白
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Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-223) protein (His tag)
UCHL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-220) protein (His tag)UCHL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 1-223) protein (GST tag)UCHL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 121-223) protein (GST tag)UCHL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (AA 101-190) protein (GST tag)UCHL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (Active) protein (His tag)UCHL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 97 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
- 别名
- UCHL1/PGP9.5 (UCHL1 产品)
- 别名
- PARK5 Protein, PGP 9.5 Protein, PGP9.5 Protein, PGP95 Protein, Uch-L1 Protein, UCH-L1 Protein, UCHL1 Protein, cb358 Protein, wu:fc55h08 Protein, park5 Protein, pgp9.5 Protein, uch-l1 Protein, MGC132191 Protein, uchl1 Protein, AW822034 Protein, C88048 Protein, R75593 Protein, UCHL-1 Protein, gad Protein, ubiquitin C-terminal hydrolase L1 Protein, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Protein, ubiquitin C-terminal hydrolase L1 L homeolog Protein, ubiquitin carboxyl-terminal esterase L1 Protein, ubiquitin carboxy-terminal hydrolase L1 Protein, UCHL1 Protein, uchl1 Protein, uchl1.L Protein, LOC100304750 Protein, Uchl1 Protein
- 背景
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Background: Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons.
Synonym: UCHL1
- 分子量
- 26.2 kDa
- UniProt
- Q00981
- 途径
- Feeding Behaviour
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