TPSB2 Protein (His tag)
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- 抗原 See all TPSB2 蛋白
- TPSB2 (Tryptase beta 2 (TPSB2))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This TPSB2 protein is labelled with His tag.
- 原理
- Recombinant Mouse MCPT6/Mast Cell Protease-6 Protein (His Tag)
- 序列
- Ala23-Ser276
- 产品特性
- Recombinant Mouse MCPT6 is produced by our Mammalian expression system and the target gene encoding Ala23-Ser276 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TPSB2 蛋白
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Tryptase beta 2 (TPSB2) (AA 32-276) protein (His tag)
TPSB2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tryptase beta 2 (TPSB2) (AA 1-275) protein (GST tag)TPSB2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Tryptase beta 2 (TPSB2) (AA 32-276) protein (GST tag)TPSB2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl,150 mMNacl, pH 7.5.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- TPSB2 (Tryptase beta 2 (TPSB2))
- 别名
- MCPT6/Mast Cell Protease-6 (TPSB2 产品)
- 别名
- TPS2 Protein, tryptaseB Protein, tryptaseC Protein, Mcpt6 Protein, tryptase beta 2 (gene/pseudogene) Protein, tryptase beta 2 Protein, TPSB2 Protein, Tpsb2 Protein
- 背景
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Background: Tryptase beta-2(Tpsb2), also known as Mast cell protease 6( mMCP-6), belongs to the peptidase S1 family and Tryptase subfamily. Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It plays a role in innate immunity. Tpsb2 can be detected primarily in skin during embryogenesis. Tpsb2 can not be detected at early embryonic stages but is abundantly expressed in later stages with a peak at E17.5-E18.5. Tryptase is a homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.
Synonym: Tryptase beta-2, Tryptase-2, Mast cell protease 6, mMCP-6, Tpsb2
- 分子量
- 29.3 kDa
- UniProt
- P21845
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