TRIB3 Protein (GST tag)
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- 抗原 See all TRIB3 蛋白
- TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This TRIB3 protein is labelled with GST tag.
- 原理
- Recombinant Human TRIB3/TRB3 Protein (GST Tag)
- 序列
- Met 1-Gly 358
- 产品特性
- A DNA sequence encoding the human TRIB3 (NP_066981.2) (Met 1-Gly 358) was fused with the GST tag at N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TRIB3 蛋白
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Tribbles Homolog 3 (Drosophila) (TRIB3) (AA 1-358) protein (GST tag)
TRIB3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Tribbles Homolog 3 (Drosophila) (TRIB3) (AA 56-145) protein (GST tag)TRIB3 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Tribbles Homolog 3 (Drosophila) (TRIB3) (AA 1-358) protein (Strep Tag)Crystallography grade TRIB3 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Tribbles Homolog 3 (Drosophila) (TRIB3) (AA 1-354) protein (Strep Tag)Crystallography grade TRIB3 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 0.5 mM Reduced Glutathione, 10 % glycerol, 0.5 mM PMSF
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- TRIB3 (Tribbles Homolog 3 (Drosophila) (TRIB3))
- 别名
- TRIB3/TRB3 (TRIB3 产品)
- 别名
- zgc:76966 Protein, TRIB3 Protein, C20orf97 Protein, NIPK Protein, SINK Protein, SKIP3 Protein, TRB3 Protein, Ifld2 Protein, Nipk Protein, TRB-3 Protein, Trb3 Protein, tribbles pseudokinase 3 Protein, trib3 Protein, TRIB3 Protein, Trib3 Protein
- 背景
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Background: Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein which belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. TRIB3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. TRIB3 may bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. It binds to ATF4 and inhibits its transcriptional activation activity. TRIB3 interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. It interacts with MAPK kinases and regulates activation of MAP kinases. It may play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. TRIB3 does not display kinase activity.
Synonym: C20orf97;NIPK;SINK;SKIP3;TRB3
- 分子量
- 65.8 kDa
- NCBI登录号
- NP_066981
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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