TGFB1 蛋白
Quick Overview for TGFB1 蛋白 (ABIN7321247)
抗原
See all TGFB1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Rat TGFB1/TGF-beta 1 Protein (Active)
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序列
- Ala279-Ser390
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产品特性
- A DNA sequence encoding the rat TGFB1 (P17246)(Ala279-Ser390) was expressed. Rat and Mouse mature TGFB1 sequences are identical.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
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Biological Activity Comment
- Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is 0.2-0.8 ng/mL.
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Transforming Growth Factor, beta 1 (TGFB1) (AA 30-278) protein (His-Avi Tag,Biotin)
TGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) proteinTGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) protein (AVI tag,Biotin)TGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Transforming Growth Factor, beta 1 (TGFB1) (AA 30-390) (Active) protein (His tag)TGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Transforming Growth Factor, beta 1 (TGFB1) (AA 30-390) (Active) protein (His tag,AVI tag,Biotin)TGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Transforming Growth Factor, beta 1 (TGFB1) (AA 30-278) (Active) protein (His tag,AVI tag,Biotin)TGFB1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Transforming Growth Factor, beta 1 (TGFB1) (Active) proteinTGFB1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active
Transforming Growth Factor, beta 1 (TGFB1) (AA 30-278) protein (His tag)TGFB1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) protein (GST tag)TGFB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, beta 1 (TGFB1) (AA 281-390) protein (GST tag)TGFB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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别名
- TGFB1/TGF-beta 1
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背景
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Background: TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
Synonym: TGF-beta 1,TGFB,TGFbeta
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分子量
- 12.8 kDa
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UniProt
- P17246
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途径
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
抗原
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