SPG21 Protein (GST tag)
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- 抗原 See all SPG21 蛋白
- SPG21 (Spastic Paraplegia 21 (SPG21))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This SPG21 protein is labelled with GST tag.
- 原理
- Recombinant Human SPG21 Protein (GST Tag)
- 序列
- Met 1-Gln 308
- 产品特性
- A DNA sequence encoding the full length of human SPG21 (NP_057714.1) (Met 1-Gln 308) was expressed with the GST tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SPG21 蛋白
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Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (His tag)
SPG21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (GST tag)SPG21 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Spastic Paraplegia 21 (SPG21) (AA 211-306) protein (GST tag)SPG21 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Spastic Paraplegia 21 (SPG21) protein (GST tag,His tag)SPG21 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Spastic Paraplegia 21 (SPG21) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SPG21 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Spastic Paraplegia 21 (SPG21) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)SPG21 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SPG21 (Spastic Paraplegia 21 (SPG21))
- 别名
- SPG21 (SPG21 产品)
- 别名
- ACP33 Protein, GL010 Protein, MAST Protein, BM-019 Protein, C78576 Protein, D9Wsu18e Protein, Maspardin Protein, wu:fd07h02 Protein, zgc:73091 Protein, SPG21, maspardin Protein, spastic paraplegia 21 (autosomal recessive, Mast syndrome) Protein, SPG21, maspardin S homeolog Protein, SPG21 Protein, Spg21 Protein, spg21.S Protein, spg21 Protein
- 背景
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Background: Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 308 amino acid residue protein widely expressed in all tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. SPG21 binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation via the noncatalytic alpha/beta hydrolase fold domain. SPG21 thus is proposed to play a role as a negative regulatory factor in CD4-dependent T-cell activation of CD4. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21, also known as Mast syndrome, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. SPG21 is also associated with dementia and other central nervous system abnormalities.
Synonym: ACP33,BM-019,GL010,MAST
- 分子量
- 61 kDa
- NCBI登录号
- NP_057714
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