SIGIRR Protein (His tag)
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- 抗原 See all SIGIRR 蛋白
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SIGIRR protein is labelled with His tag.
- 原理
- Recombinant Human SIGIRR/TIR8 Protein (His Tag)
- 序列
- Met 1-His 118
- 产品特性
- A DNA sequence encoding the human SIGIRR (Q6IA17-1) extracellular domain (Met 1-His 118) was expressed, fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SIGIRR 蛋白
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Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) protein (GST tag)
SIGIRR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) protein (His tag,Fc Tag)SIGIRR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) protein (Strep Tag)Crystallography grade SIGIRR 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-409) protein (Strep Tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-117) protein (His tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 140-410) protein (His tag)Crystallography grade SIGIRR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 139-409) protein (His tag)Crystallography grade SIGIRR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 别名
- SIGIRR/TIR8 (SIGIRR 产品)
- 别名
- TIR8 Protein, AI256711 Protein, sc:d148 Protein, RGD1306732 Protein, single Ig and TIR domain containing Protein, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Protein, SIGIRR Protein, Sigirr Protein, sigirr Protein
- 背景
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Background: Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.
Synonym: TIR8
- 分子量
- 14 kDa
- 途径
- Toll-Like Receptors Cascades
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