SIRPb2 Protein (Fc Tag)
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- 抗原 See all SIRPb2 products
- SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- 人细胞
- 标记
- This SIRPb2 protein is labelled with Fc Tag.
- 原理
- Recombinant Human SIRPB2 (C-Fc)
- 序列
- Gln33-Gly287
- 产品特性
- Recombinant Human Signal-regulatory Protein Beta-2 is produced by our Mammalian expression system and the target gene encoding Gln33-Gly287 is expressed with a Fc tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Signal-Regulatory Protein beta 2 (SIRPb2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)
SIRPb2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SIRPb2 (Signal-Regulatory Protein beta 2 (SIRPb2))
- 别名
- SIRPB2 (SIRPb2 产品)
- 别名
- PTPN1L Protein, PTPNS1L3 Protein, dJ776F14.2 Protein, SIRPG Protein, SIRPB2 Protein, signal regulatory protein beta 2 Protein, signal-regulatory protein beta-2 Protein, SIRPB2 Protein, LOC100146829 Protein
- 背景
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Background: Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
Synonym: dJ776F14.2, PTPN1L, PTPNS1L3, Signal-Regulatory Protein Beta 2, Signal-Regulatory Protein Beta-2, SIRP beta 2, SIRP-beta-2, SIRPG
- 分子量
- 55.2 kDa
- UniProt
- Q5JXA9
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