SIGLEC8 Protein (His tag)
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- 抗原 See all SIGLEC8 蛋白
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- 人细胞
- 标记
- This SIGLEC8 protein is labelled with His tag.
- 原理
- Recombinant Human Siglec-8 (C-6His)
- 序列
- Met17-Ala363
- 产品特性
- Recombinant Human Sialic Acid-binding Ig-like Lectin 8 is produced by our Mammalian expression system and the target gene encoding Met17-Ala363 is expressed with a 6His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SIGLEC8 蛋白
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Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 17-363) protein (Fc Tag)
SIGLEC8 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 18-121) protein (GST tag)SIGLEC8 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) (AA 17-363) protein (His-Avi Tag)SIGLEC8 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) protein (mFc Tag)SIGLEC8 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) protein (His-Avi Tag,Biotin)SIGLEC8 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
- 别名
- Siglec-8 (SIGLEC8 产品)
- 别名
- SAF2 Protein, SIGLEC-8 Protein, SIGLEC8L Protein, SIGLEC8 Protein, sialic acid binding Ig like lectin 8 Protein, sialic acid-binding Ig-like lectin 8 Protein, SIGLEC8 Protein, LOC506364 Protein
- 背景
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Background: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs. Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation (9). It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Synonym: Siglec8, Siglec-8, SAF2, SAF2SAF-2, SAF-2, CD329 antigen, CDw329
- 分子量
- 38.6 kDa
- UniProt
- Q9NYZ4
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