STK26/MST4 Protein (GST tag)
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- 抗原 See all STK26/MST4 (MST4) 蛋白
- STK26/MST4 (MST4) (Serine/threonine-Protein Kinase MST4 (MST4))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This STK26/MST4 protein is labelled with GST tag.
- 原理
- Recombinant Human MST4 Protein (GST Tag)(Active)
- 序列
- Met 1-Pro 416
- 产品特性
- A DNA sequence encoding the human MST4 isoform 1 (NP_057626.2) (Met 1-Pro 416) was expressed with the fused GST tag at N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 15 nmol/min/mg using MBP as substrate.
- Top Product
- Discover our top product MST4 蛋白
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Serine/threonine-Protein Kinase MST4 (MST4) (AA 1-416) (Active) protein (His-GST)
MST4 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Serine/threonine-Protein Kinase MST4 (MST4) (AA 1-137) protein (GST tag)MST4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Serine/threonine-Protein Kinase MST4 (MST4) (AA 1-90) protein (GST tag)MST4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Serine/threonine-Protein Kinase MST4 (MST4) (AA 331-415) protein (GST tag)MST4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Serine/threonine-Protein Kinase MST4 (MST4) (AA 2-416) protein (His tag)Crystallography grade MST4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Serine/threonine-Protein Kinase MST4 (MST4) (AA 2-416) protein (His tag)Crystallography grade MST4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Serine/threonine-Protein Kinase MST4 (MST4) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MST4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 25 % glycerol, 0.6 mM GSH, 0.5 mM PMSF, 0.5 mM EDTA, 2 mM DTT
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- STK26/MST4 (MST4) (Serine/threonine-Protein Kinase MST4 (MST4))
- 别名
- MST4 (MST4 产品)
- 别名
- Mst4 Protein, MASK Protein, RGD1563568 Protein, serine/threonine kinase 26 Protein, Stk26 Protein, STK26 Protein
- 背景
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Background: MST4, also known as mammalian STE20-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste20-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transient transfected cells or in stable cell lines, and thus is biologically active in the activation of MEK/ERK pathway mediating cell growth and transformation. Further, MST4 kinase activity is stimulated significantly by epidermal growth factor receptor (EGFR) ligands, which are known to promote growth of certain cancer cells. Accordingly, MST4 have a potential role in signal transduction pathways involved in cancer progression. Three alternatively spliced isoform of MST4 have been isolated, and isoform 3 lacks an exon encoding kinase domain and may function as a dominant-negative regulator of the MST4 kinase.
Synonym: MASK,MST4
- 分子量
- 73 kDa
- NCBI登录号
- NP_057626
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