SPINT2 Protein (His tag)
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- 抗原 See all SPINT2 蛋白
- SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This SPINT2 protein is labelled with His tag.
- 原理
- Recombinant Mouse HAI-2/SPINT2 Protein (His Tag)
- 序列
- Met 1-Lys 140
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Lys 140) of mouse SPINT2 (NP_001076017.1) precursor was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product SPINT2 蛋白
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serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) protein (His tag)
SPINT2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) (AA 1-252) protein (GST tag)SPINT2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) (AA 28-197) protein (His tag)Crystallography grade SPINT2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) (AA 28-252) protein (rho-1D4 tag)Crystallography grade SPINT2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) (AA 28-252) protein (rho-1D4 tag)Crystallography grade SPINT2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2) protein (Myc-DYKDDDDK Tag)SPINT2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SPINT2 (serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
- 别名
- HAI-2/SPINT2 (SPINT2 产品)
- 别名
- HAI-2 Protein, Pb Protein, DIAR3 Protein, HAI2 Protein, Kop Protein, PB Protein, AL024025 Protein, C76321 Protein, serine peptidase inhibitor, Kunitz type, 2 Protein, serine peptidase inhibitor, Kunitz type 2 Protein, serine protease inhibitor, Kunitz type 2 Protein, Spint2 Protein, SPINT2 Protein
- 背景
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Background: Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.
Synonym: AL024025,C76321,HAI-2
- 分子量
- 14 kDa
- NCBI登录号
- NP_001076017
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