Selectin E/CD62e Protein (Fc Tag)
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- 抗原 See all Selectin E/CD62e (SELE) 蛋白
- Selectin E/CD62e (SELE) (Selectin E (SELE))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This Selectin E/CD62e protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse E-Selectin/SELE Protein (Fc Tag)(Active)
- 序列
- Met1-Pro564
- 产品特性
- A DNA sequence encoding the mouse SELE (NP_035475.1)(Met1-Pro564) was expressed with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When cells are added to coated plates (10 μg/ml, 100 μl/well), approximately 50% will adhere specifically after 60 minutes at 37 °C.
- Top Product
- Discover our top product SELE 蛋白
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Selectin E (SELE) (AA 22-556) protein (His-Avi Tag)
SELE 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Selectin E (SELE) (AA 22-556) protein (Fc Tag)SELE 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Selectin E (SELE) (AA 22-554) protein (His tag)SELE 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Selectin E (SELE) protein (His-Avi Tag,Biotin)SELE 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Selectin E (SELE) (AA 22-557) protein (His tag)SELE 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Selectin E (SELE) (AA 1-610) protein (GST tag)SELE 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Selectin E (SELE) (AA 401-500) protein (GST tag)SELE 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Selectin E (SELE) (Active) protein (His tag)SELE 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Selectin E (SELE) (Active) protein (Fc Tag)SELE 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Selectin E (SELE) (Active) protein (His tag)SELE 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Selectin E/CD62e (SELE) (Selectin E (SELE))
- 别名
- E-Selectin/SELE (SELE 产品)
- 别名
- SELE Protein, CD62E Protein, ELAM Protein, ELAM1 Protein, ESEL Protein, LECAM2 Protein, E-selectin Protein, Elam Protein, selectin E Protein, selectin, endothelial cell Protein, SELE Protein, Sele Protein
- 背景
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Background: E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.
Synonym: CD62E,E-selectin,Elam
- 分子量
- 85.5 kDa
- NCBI登录号
- NP_035475
- 途径
- Thromboxane A2 Receptor Signaling
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