SCGB1A1 Protein (His tag)
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- 抗原 See all SCGB1A1 蛋白
- SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This SCGB1A1 protein is labelled with His tag.
- 原理
- Recombinant Human Uteroglobin/SCGB1A1 Protein (His Tag)(Active)
- 序列
- Met 1-Asn 91
- 产品特性
- A DNA sequence encoding the human SCGB1A1 (P11684) (Met 1-Asn 91) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line. When 5 x 10E4cells/well are added to human SCGB1A1 coated plates (2 μg/ml and 100 μl/well), approximately >30% will adhere after one hour at 37 °C.
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- Discover our top product SCGB1A1 蛋白
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Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) (Active) protein
SCGB1A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) (AA 1-91) protein (GST tag)SCGB1A1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) (AA 22-91) protein (GST tag)SCGB1A1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) (AA 22-91) protein (His tag)Crystallography grade SCGB1A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SCGB1A1 (Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1))
- 别名
- Uteroglobin/SCGB1A1 (SCGB1A1 产品)
- 别名
- CC10 Protein, CC16 Protein, CCPBP Protein, CCSP Protein, UGB Protein, UP-1 Protein, UP1 Protein, UGL Protein, PCB-BP Protein, UG Protein, Utg Protein, PCBB Protein, Ugb Protein, SCGB1A1 Protein, secretoglobin family 1A member 1 Protein, secretoglobin, family 1A, member 1 (uteroglobin) Protein, urinary protein 2 Protein, SCGB1A1 Protein, Scgb1a1 Protein, Rup2 Protein
- 背景
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Background: Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10- kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.
Synonym: Uteroglobin, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1, SCGB1A1, CCSP, UGB
- 分子量
- 9.2 kDa
- UniProt
- P11684
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