Sclerostin Protein (SOST) (His tag)
Quick Overview for Sclerostin Protein (SOST) (His tag) (ABIN7320639)
抗原
See all Sclerostin (SOST) 蛋白蛋白类型
宿主
资源
纯度
-
-
标记
- This Sclerostin protein is labelled with His tag.
-
原理
- Recombinant Mouse Sclerostin/SOST Protein (His Tag)
-
序列
- Gln24-Tyr211
-
产品特性
- Recombinant Mouse Sclerostin is produced by our Mammalian expression system and the target gene encoding Gln24-Tyr211 is expressed with a 6His tag at the C-terminus.
-
内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
-
-
Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag)
SOST 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag,Biotin)SOST 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 69-258) protein (His tag)SOST 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) protein (His tag)SOST 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Sclerostin (SOST) (AA 24-213) protein (His tag,Biotin)SOST 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Please refer to the printed manual for detailed information.
-
缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- Sclerostin (SOST)
-
别名
- Sclerostin/SOST
-
背景
-
Background: Sclerostin (SOST) is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. While the overall sequence identity between members of the family is low, they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization? however, SOST does not and is secreted as a monomer. SOST was originally identified as an important regulator of bone homeostasis. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones. SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-induced osteogenesis. SOST has been shown to have unique ligand specificity, binding BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity.
Synonym: Sclerostin, Sost
-
分子量
- 21.9 kDa
-
UniProt
- Q99P68
抗原
-
