Sclerostin Protein (SOST) (His tag)
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Quick Overview for Sclerostin Protein (SOST) (His tag) (ABIN7197841)
抗原
See all Sclerostin (SOST) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Sclerostin protein is labelled with His tag.
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原理
- Recombinant Rat Sclerostin/SOST Protein (His Tag)
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序列
- Met 1-Tyr 213
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产品特性
- A DNA sequence encoding the rat SOST (NP_085073.1) (Met 1-Tyr 213) was expressed, fused with a polyhistidine tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag)
SOST 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-213) (Active) protein (Biotin,His-Avi Tag)SOST 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 69-258) (Active) protein (His tag)SOST 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 24-211) protein (His tag)SOST 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Sclerostin (SOST) (AA 24-213) protein (His tag,Biotin)SOST 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Sclerostin (SOST)
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别名
- Sclerostin/SOST
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背景
- SOST,Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
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分子量
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Calculated MW: 23 kDa
Observed MW: 33 kDa
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NCBI登录号
- NP_085073
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UniProt
- A6HJF6
抗原
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