Retinoblastoma Binding Protein 4 Protein (RBBP4) (His tag)
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- 抗原 See all Retinoblastoma Binding Protein 4 (RBBP4) 蛋白
- Retinoblastoma Binding Protein 4 (RBBP4)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This Retinoblastoma Binding Protein 4 protein is labelled with His tag.
- 原理
- Recombinant Human RBBP4/RBAP48 Protein (His Tag)
- 序列
- Met 1-Ser 425
- 产品特性
- A DNA sequence encoding the full length of human RBBP4 (NP_005601.1) (Met 1-Ser 425) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product RBBP4 蛋白
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Retinoblastoma Binding Protein 4 (RBBP4) (AA 1-425) protein (His tag)
RBBP4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Retinoblastoma Binding Protein 4 (RBBP4) (AA 1-425) protein (GST tag)RBBP4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Retinoblastoma Binding Protein 4 (RBBP4) (AA 2-425) protein (His tag)Crystallography grade RBBP4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Retinoblastoma Binding Protein 4 (RBBP4) (AA 2-425) protein (His tag)Crystallography grade RBBP4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Retinoblastoma Binding Protein 4 (RBBP4) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)RBBP4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM TCEP, 10 % glycerol, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Retinoblastoma Binding Protein 4 (RBBP4)
- 别名
- RBBP4/RBAP48 (RBBP4 产品)
- 别名
- NURF55 Protein, RBAP48 Protein, 154659_at Protein, 55 Protein, CAF-1 Protein, CAF1 Protein, CAF1-55 Protein, CAF1p55 Protein, CG4236 Protein, Caf-1 Protein, Caf1/p55 Protein, Caf1p55 Protein, Dmel\\CG4236 Protein, MSI1/RbAp48/CAC3/LIN-53 Protein, NURF Protein, NURF-55 Protein, Nurf Protein, Nurf 55 Protein, Nurf-55 Protein, Nurf55 Protein, P55 Protein, RbAp48 Protein, S(ls)3 Protein, caf-1 Protein, caf1 Protein, caf1 p55 Protein, d-CAF1 Protein, dCAF-1 Protein, dCAF-1 p55 Protein, dNURF Protein, p55 Protein, p55 CAF1 Protein, p55/NURF-55 Protein, p55CAF1 Protein, nurf55 Protein, rbap48 Protein, xrbbp4 Protein, mRbAp48 Protein, RBBP4 Protein, rbb4-2 Protein, zgc:55349 Protein, zgc:77854 Protein, wu:fb33a09 Protein, wu:fb40e10 Protein, RBBP-4 Protein, rbbp4 Protein, M4E13.110 Protein, M4E13_110 Protein, MULTICOPY SUPPRESSOR OF IRA1 3 Protein, NFC3 Protein, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP C 3 Protein, RB binding protein 4, chromatin remodeling factor Protein, Chromatin assembly factor 1, p55 subunit Protein, retinoblastoma binding protein 4 Protein, retinoblastoma binding protein 4, chromatin remodeling factor Protein, retinoblastoma binding protein 4 L homeolog Protein, Transducin family protein / WD-40 repeat family protein Protein, retinoblastoma binding protein 4 S homeolog Protein, RBBP4 Protein, Caf1-55 Protein, rbbp4 Protein, Rbbp4 Protein, rbbp4.L Protein, MSI3 Protein, rbbp4.S Protein
- 背景
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Background: Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling factor subunit RBAP48 and RBBP4, is a nucleus protein which belongs to the WD repeat RBAP46/RBAP48/MSI1 family. RBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling and the NURF (nucleosome remodeling factor) complex. One common myth is that age-related memory loss is an early indication of Alzheimer's disease. But researchers at the Columbia University Medical Center in New York City have found a specific protein, RbAp48, that they believe is responsible for age-related memory problems. What's more, by replenishing RbAp48 in the brains of mice, the researchers were able to undo existing age-related memory damage. To find RbAp48, researchers focused on the hippocampus, the region of the brain where memories are formed. After studying eight healthy brains donated to science by people between the ages of 33 and 88, they found that RbAp48 was reduced by nearly 50 percent in the older brains. The researchers found that when they turned off RbAp48 in younger mice, they became more forgetful, while increasing RbAp48 in older mice restored memory. The mice were given memory tests that included object recognition and water maze problems.
Synonym: lin-53;NURF55;RBAP48
- 分子量
- 50 kDa
- NCBI登录号
- NP_005601
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
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