QPRT Protein (His tag)
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- 抗原 See all QPRT 蛋白
- QPRT (Quinolinate Phosphoribosyltransferase (QPRT))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This QPRT protein is labelled with His tag.
- 原理
- Recombinant Human QPRT/QPRTase Protein (His Tag)
- 序列
- Met 1-His297
- 产品特性
- Recombinant Human Quinolinate Phosphoribosyltransferase [Decarboxylating] is produced by our E.coli expression system and the target gene encoding Met1-His297 is expressed with a 6His tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product QPRT 蛋白
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- QPRT (Quinolinate Phosphoribosyltransferase (QPRT))
- 别名
- QPRT/QPRTase (QPRT 产品)
- 别名
- ECK0108 Protein, JW0105 Protein, VF2184 Protein, QPRTase Protein, 2410027J01Rik Protein, AI647766 Protein, quinolinate phosphoribosyltransferase Protein, nicotinate-nucleotide pyrophosphorylase Protein, nicotinate-nucleotide diphosphorylase Protein, carboxylating Protein, ECs0113 Protein, nadC Protein, VP2522 Protein, STY0167 Protein, BJE04_RS13210 Protein, QPRT Protein, Qprt Protein
- 背景
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Background: Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
Synonym: Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating], Quinolinate Phosphoribosyltransferase [Decarboxylating], QAPRTase, QPRTase, QPRT
- 分子量
- 33.0 kDa
- UniProt
- Q15274
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