CD45 Protein (His tag)
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- 抗原 See all CD45 (PTPRC) 蛋白
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This CD45 protein is labelled with His tag.
- 原理
- Recombinant Mouse CD45/PTPRC (C-6His)
- 序列
- Gln26--Lys566
- 产品特性
- Recombinant Mouse Receptor-type Tyrosine-protein Phosphatase C is produced by our Mammalian expression system and the target gene encoding Gln26-Lys566 is expressed with a 6His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PTPRC 蛋白
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Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 26-577) protein (His tag)
PTPRC 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 26-416) protein (His-Avi Tag)PTPRC 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 26-416) protein (His-Avi Tag,Biotin)PTPRC 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 1031-1251) protein (His tag)PTPRC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 915-1306) protein (His tag)PTPRC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 1207-1304) protein (GST tag)PTPRC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 390-570) protein (GST tag)PTPRC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (Active) protein (Fc Tag)PTPRC 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (Active) proteinPTPRC 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (Active) protein (GST tag,His tag)PTPRC 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
- 别名
- CD45/PTPRC (PTPRC 产品)
- 别名
- PTPRC Protein, si:dkeyp-47c5.1 Protein, B220 Protein, CD45 Protein, CD45R Protein, GP180 Protein, L-CA Protein, LCA Protein, LY5 Protein, T200 Protein, Cd45 Protein, Ly-5 Protein, Lyt-4 Protein, loc Protein, Lca Protein, RT7 Protein, cd45 Protein, protein tyrosine phosphatase, receptor type C Protein, protein tyrosine phosphatase, receptor type, C Protein, receptor-type tyrosine-protein phosphatase C Protein, PTPRC Protein, ptprc Protein, LOC100074271 Protein, Ptprc Protein
- 背景
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Background: Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin. CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates. Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK. In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148. CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders.
Synonym: B220, CD45 antigen, CD45, CD45R, LCA, L-CA, LY5, protein tyrosine phosphatase, receptor type, C, PTPRC, receptor-type tyrosine-protein phosphatase C
- 分子量
- 59.5 kDa
- UniProt
- P06800
- 途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
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