PTPMT1 Protein (His tag)
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- 抗原 See all PTPMT1 蛋白
- PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PTPMT1 protein is labelled with His tag.
- 原理
- Recombinant Human PTPMT1 Protein (His Tag)(Active)
- 序列
- Lys 28-Thr 201
- 产品特性
- A DNA sequence encoding the human PTPMT1 isoform 1 (Q8WUK0-1) (Lys 28-Thr 201) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 94 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to cleave pNPP.The specific activity is >200 pmoles/min/μg.
- Top Product
- Discover our top product PTPMT1 蛋白
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Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) (AA 28-201) protein (His tag)
PTPMT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) (AA 1-201) protein (GST tag)PTPMT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) (AA 32-193) protein (His tag)Crystallography grade PTPMT1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) (AA 28-201) protein (His-SUMO Tag)PTPMT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 10 % glycerol, 1 mM DTT, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))
- 别名
- PTPMT1 (PTPMT1 产品)
- 别名
- im:7137979 Protein, zgc:158719 Protein, DUSP23 Protein, MOSP Protein, PLIP Protein, 1110001D10Rik Protein, 2810004N20Rik Protein, Plip Protein, protein tyrosine phosphatase, mitochondrial 1 Protein, PTPMT1 Protein, ptpmt1 Protein, Ptpmt1 Protein
- 背景
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Background: PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an accumulation of PGP along with a concomitant decrease in phosphatidylglycerol. Modulation of mitochondrial ATP synthesis by PTPMT1 suggests a novel approach for the treatment of pancreatic cancers, which represent some of the deadliest forms of human tumors. The gluttony of cancer cells for energy is well established, and with the development of a modulator of expression, one may hope that we could also achieve the synthetic induction of PTPMT1 expression. It would then be expected that this effect would attenuate, if not abolish, the growth of pancreas-derived tumor cells and support the establishment of a novel regimen for pancreatic cancers.
Synonym: DUSP23;FLJ46081;MOSP;PLIP;PNAS-129
- 分子量
- 21.7 kDa
- 途径
- Inositol Metabolic Process
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