PPM1A Protein (His tag)
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- 抗原 See all PPM1A 蛋白
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PPM1A protein is labelled with His tag.
- 原理
- Recombinant Human PPM1A Protein (His Tag)
- 序列
- Gly2-Trp382
- 产品特性
- Recombinant Human Protein Phosphatase 1A is produced by our E.coli expression system and the target gene encoding Gly2-Trp382 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- Discover our top product PPM1A 蛋白
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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 1-382) (Active) protein
PPM1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 1-382) protein (GST tag)PPM1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) protein (His tag)PPM1A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 98 % as determined by SDS-PAGE
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 2-382) protein (His tag)Crystallography grade PPM1A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (AA 2-382) protein (His tag)Crystallography grade PPM1A 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (His tag)PPM1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PPM1A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
- 别名
- PPM1A (PPM1A 产品)
- 别名
- PP2C-ALPHA Protein, PP2CA Protein, PP2Calpha Protein, pp2ca1 Protein, ppp1r13b Protein, si:ch211-253p18.1 Protein, wu:fd42g12 Protein, zgc:153820 Protein, 2310003C21Rik Protein, 2900017D14Rik Protein, AI427932 Protein, AU017636 Protein, MMPa-2 Protein, MPPa-1 Protein, Pp2c1 Protein, pp2c-alpha Protein, pp2ca Protein, pp2calpha Protein, pp2ca2 Protein, protein phosphatase, Mg2+/Mn2+ dependent 1A Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab Protein, protein phosphatase 1A, magnesium dependent, alpha isoform Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1A Protein, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog Protein, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa Protein, PPM1A Protein, ppm1ab Protein, Ppm1a Protein, ppm1a.L Protein, ppm1aa Protein
- 背景
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Background: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
Synonym: Protein Phosphatase 1A, Protein Phosphatase 2C Isoform Alpha, PP2C-Alpha, Protein Phosphatase IA, PPM1A, PPPM1A,PP2C-ALPHA,PP2CA,PP2Calpha
- 分子量
- 43.5 kDa
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